| Year | American League Season Leaders | |||||||
| ERA | Wins | Strikeouts | Saves | |||||
| 1960 | Muffett-Bos | 1.94 | Wynn-Chi | 20 | Bunning-Det | 199 | Staley-Chi | 28 |
| 1961 | Pascual-Min | 2.49 | Pascual-Min | 21 | Pizzaro-Chi | 214 | Wilhelm-Bal | 31 |
| 1962 | Agguire-Det | 1.99 | Terry-NY | 21 | Pascual-Min | 245 | Funk-Cle | 27 |
| 1963 | Downing-NY | 2.41 | 2 Tied[1] | 19 | 2 Tied[2] | 217 | Miller-Bal | 30 |
| 1964 | Bouton-NY | 2.10 | Bouton-NY | 23 | Lolich-Det | 248 | Radatz-Bos | 31 |
| 1965 | McDowell-Cle | 1.98 | McDowell-Cle | 22 | McDowell-Cle | 325 | Lee-LA | 31 |
| 1966 | Peters-Chi | 2.02 | Stottlemyre-NY | 23 | McDowell-Cle | 261 | Aker-KC | 29 |
| 1967 | Downing-NY | 1.89 | Lonborg-Bos | 24 | Lonborg-Bos | 265 | Rojas-Cal | 29 |
| 1969 | Cuellar-Bal | 1.79 | Cuellar-Bal | 26 | McDowell-Cle | 265 | Perranoski-Min | 28 |
| 1970 | Messersmith-Cal | 2.41 | Hunter-Oak | 25 | McDowell-Cle (4) | 271 | Grant-Oak | 37 |
| 1971 | Palmer-Bal | 1.94 | Palmer-Bal | 25 | Blue-Oak | 277 | Lyle-Bos | 24 |
| 1972 | Hunter-Oak | 1.37 | Hunter-Oak (2) | 26 | Ryan-Cal | 346 | Lyle-NY (2) | 20 |
| 1973 | Palmer-Bal (2) | 2.68 | Blyleven-Mil | 24 | Ryan-Cal (2) | 365 | Hiller-Det | 28 |
| 1980 | Norris-Oak | 2.04 | Gura-KC | 23 | Barker-Cle | 187 | Stoddard-Bal | 35 |
| 1982 | Barker-Cle | 2.80 | John-NY/Cal | 22 | Bannister-Sea | 206 | Caudill-Sea | 34 |
| 1985 | Clancy-Tor | 2.52 | Boyd-Bos | 23 | Morris-Det | 222 | 4 Tied[3] | 28 |
| 1986 | Clemens-Bos | 1.99 | Clemens-Bos | 22 | Langston-Sea | 268 | Righetti-NY | 44 |
| 1987 | Key-Tor | 2.40 | Viola-Min | 25 | Clemens-Bos | 258 | Henke-Tor | 34 |
| 1990 | Hibbard-Chi | 2.20 | Stewart-Oak | 25 | Ryan-Tex | 249 | Eckersley-Oak | 52 |
| 2004 | Santana-Min | 2.26 | Santana-Min | 20 | Santana-Min | 264 | Nathan-Min | 42 |
| 2005 | Millwood-Cle | 2.76 | Clement-Bos | 19 | Santana-Min | 259 | Rivera-NY | 38 |
| 2006 | Santana-Min (2) | 2.92 | 2 Tied[4] | 20 | Santana-Min (3) | 260 | Jones-Det | 44 |
| 2007 | Buehrle-Chi | 3.00 | 2 Tied[5] | 18 | Kazmir-Tam | 240 | Nathan-Min (2) | 35 |
| 2008 | Santana-LA | 2.74 | Shields-Tam | 20 | Santana-LA | 228 | Rivera-NY | 41 |
| 2009 | Greinke-KC | 2.39 | 2 Tied[6] | 19 | Verlander-Det | 282 | Rodney-Det | 35 |
| 2010 | Braden-Oak | 2.58 | Lester-Bos | 23 | Weaver-LA | 252 | Felix-Tex | 46 |
| 2011 | Beckett-Bos | 2.28 | Haren-LA | 25 | Price-Tam | 259 | Papelbon-Bos | 52 |
| 2012 | Price-Tam | 2.74 | Price-Tam | 22 | Scherzer-Det | 256 | Rodney-Tam | 46 |
| 2013 | Hernandez-Sea | 2.43 | Lester-Bos (2) | 20 | Darvish-Tex | 277 | Rivera-NY (3) | 45 |
| 2014 | Sale-Chi | 1.93 | Dickey-Tor | 19 | Hernandez-Sea | 283 | Rodney-Sea (3) | 41 |
| 2015 | Price (2) | 2.25 | Dickey-Tor (2) | 19 | Sale-Chi | 284 | Osuna-Tor | 39 |
| 2016 | Sale-Chi (2) | 2.07 | 3 Tied[7] | 20 | Verlander-Det | 276 | Osuna-Tor (2) | 41 |
| 2017 | Kluber-Cle | 2.08 | Kluber-Cle | 23 | Sale-Bos (2) | 325 | Allen-Cle | 42 |
| 2018 | Verlander-Hou | 2.18 | Verlander-Hou (3) | 23 | Verlander-Hou (3) | 350 | Kimbrel-Bos | 43 |
| 2019 | Cole-Hou | 2.19 | Verlander-Hou (4) | 23 | Cole-Hou | 375 | Osuna-Hou | 43 |
| 2020 | Bundy-LA | 1.57 | 3 Tied[8] | 7 | Bieber-Cle | 138 | Pressley-Hou | 14 |
| 2021 | McCullers-Hou | 2.47 | Ray-Tor | 20 | Ray-Tor | 273 | Romano-Tor | 38 |