Team game results - 2021 Toronto
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 4/1/2021 | | @ | NYA | W | 7-6 | | Ryu, H | L | Ryu, H | Romano, J | Cole, G | R |
| 4/3/2021 | | @ | NYA | W | 10-5 | | Stripling, R | R | Thornton, T | | Kluber, C | R |
| 4/4/2021 | | @ | NYA | L | 6-11 | | Zeuch, T | R | Milone, T | | German, D | R |
| 4/5/2021 | | @ | Tex | W | 7-2 | | Matz, S | L | Matz, S | | Foltynewicz, M | R |
| 4/6/2021 | | @ | Tex | L | 0-6 | | Roark, T | R | Roark, T | | Dunning, D | R |
| 4/7/2021 | | @ | Tex | W | 3-2 | | Ryu, H | L | Ryu, H | Romano, J | Gibson, K | R |
| 4/8/2021 | | | LAA | L | 3-7 | | Stripling, R | R | Stripling, R | | Canning, G | R |
| 4/9/2021 | | | LAA | L | 3-12 | | Phelps, D | R | Phelps, D | | Heaney, A | L |
| 4/10/2021 | | | LAA | W | 8-2 | | Matz, S | L | Matz, S | | Quintana, J | L |
| 4/12/2021 | | | NYA | W | 4-0 | | Ray, R | L | Ray, R | | Cole, G | R |
| 4/13/2021 | | | NYA | L | 1-11 | | Ryu, H | L | Ryu, H | | Taillon, J | R |
| 4/14/2021 | | | NYA | W | 5-1 | | Zeuch, T | R | Zeuch, T | | Kluber, C | R |
| 4/15/2021 | | @ | KC | W | 10-3 | | Kay, A | L | Kay, A | | Junis, J | R |
| 4/17/2021 | 1 | @ | KC | W | 3-2 | 7 | Matz, S | L | Matz, S | Dolis, R | Minor, M | L |
| 4/17/2021 | 2 | @ | KC | W | 6-4 | 7 | Milone, T | L | Phelps, D | Mayza, T | Santana, E | R |
| 4/18/2021 | | @ | KC | W | 6-3 | | Ray, R | L | Ray, R | | Singer, B | R |
| 4/20/2021 | | @ | Bos | L | 2-3 | | Ryu, H | L | Dolis, R | | Rodriguez, E | L |
| 4/21/2021 | | @ | Bos | W | 5-3 | | Thornton, T | R | Thornton, T | Dolis, R | Richards, G | R |
| 4/23/2021 | | @ | Tam | W | 4-2 | 10 | Matz, S | L | Phelps, D | Castro, A | Glasnow, T | R |
| 4/24/2021 | | @ | Tam | W | 9-7 | | Ray, R | L | Ray, R | Romano, J | Honeywell, B | R |
| 4/25/2021 | | @ | Tam | W | 4-3 | | Ryu, H | L | Ryu, H | Romano, J | Patino, L | R |
| 4/27/2021 | | | Was | L | 7-8 | 10 | Thornton, T | R | Borucki, R | | Scherzer, M | R |
| 4/28/2021 | | | Was | W | 17-5 | | Matz, S | L | Matz, S | | Fedde, E | R |
| 4/30/2021 | | | Atl | W | 14-4 | | Ray, R | L | Ray, R | | Smyly, D | L |
| 5/1/2021 | | | Atl | L | 4-12 | | Bergen, T | L | Bergen, T | | Morton, C | R |
| 5/2/2021 | | | Atl | L | 3-4 | | Stripling, R | R | Romano, J | | Anderson, I | R |
| 5/3/2021 | | @ | Oak | W | 2-1 | | Matz, S | L | Matz, S | Romano, J | Montas, F | R |
| 5/4/2021 | | @ | Oak | W | 7-2 | | Kay, A | L | Payamps, J | | Irvin, C | L |
| 5/5/2021 | | @ | Oak | W | 4-1 | | Ray, R | L | Ray, R | Dolis, R | Bassitt, C | R |
| 5/6/2021 | | @ | Oak | L | 6-21 | | Ryu, H | L | Ryu, H | | Fiers, M | R |
| 5/7/2021 | | @ | Hou | L | 2-3 | | Stripling, R | R | Stripling, R | | Urquidy, J | R |
| 5/8/2021 | | @ | Hou | W | 7-3 | | Matz, S | L | Matz, S | Cole, A | Javier, C | R |
| 5/9/2021 | | @ | Hou | L | 4-5 | 15 | Pearson, N | R | Kay, A | | Greinke, Z | R |
| 5/11/2021 | | @ | Atl | W | 6-3 | | Ray, R | L | Ray, R | Romano, J | Wilson, B | R |
| 5/12/2021 | | @ | Atl | W | 4-3 | | Ryu, H | L | Thornton, T | Romano, J | Fried, M | L |
| 5/13/2021 | | @ | Atl | W | 3-2 | | Stripling, R | R | Bergen, T | Romano, J | Morton, C | R |
| 5/14/2021 | | | Phi | W | 10-2 | | Matz, S | L | Matz, S | | Velasquez, V | R |
| 5/15/2021 | | | Phi | W | 5-3 | | Kay, A | L | Kay, A | Romano, J | Nola, A | R |
| 5/16/2021 | | | Phi | L | 1-4 | | Ray, R | L | Ray, R | | Anderson, C | R |
| 5/18/2021 | | | Bos | W | 4-2 | | Ryu, H | L | Ryu, H | Romano, J | Rodriguez, E | L |
| 5/19/2021 | | | Bos | W | 9-2 | | Stripling, R | R | Stripling, R | | Richards, G | R |
| 5/20/2021 | | | Bos | L | 5-8 | | Matz, S | L | Romano, J | | Pivetta, N | R |
| 5/21/2021 | | | Tam | L | 9-10 | 10 | Kay, A | L | Mayza, T | | Glasnow, T | R |
| 5/22/2021 | | | Tam | W | 5-3 | 10 | Ray, R | L | Mayza, T | | McClanahan, S | L |
| 5/23/2021 | | | Tam | L | 2-10 | | Ryu, H | L | Castro, A | | Wacha, M | R |
| 5/24/2021 | | | Tam | L | 0-2 | | Thornton, T | R | Thornton, T | | Yarbrough, R | L |
| 5/25/2021 | | @ | NYA | L | 3-4 | 10 | Matz, S | L | Romano, J | | Kluber, C | R |
| 5/27/2021 | 1 | @ | NYA | W | 6-2 | 7 | Manoah, A | R | Manoah, A | | German, D | R |
| 5/27/2021 | 2 | @ | NYA | L | 0-1 | 7 | Ray, R | L | Castro, A | | Montgomery, J | L |
| 5/28/2021 | | @ | Cle | L | 3-6 | | Ryu, H | L | Ryu, H | | Morgan, E | R |
| 5/30/2021 | 1 | @ | Cle | W | 7-5 | 7 | Stripling, R | R | Dolis, R | Romano, J | Civale, A | R |
| 5/30/2021 | 2 | @ | Cle | W | 2-1 | 7 | Matz, S | L | Mayza, T | Castro, A | Hentges, S | L |
| 6/1/2021 | | | Mia | W | 7-4 | | Ray, R | L | Ray, R | Romano, J | Alcantara, S | R |
| 6/2/2021 | | | Mia | W | 6-0 | | Manoah, A | R | Manoah, A | | Lopez, P | R |
| 6/4/2021 | | | Hou | L | 4-5 | 10 | Ryu, H | L | Mayza, T | | Greinke, Z | R |
| 6/5/2021 | | | Hou | L | 7-11 | | Stripling, R | R | Payamps, J | | Urquidy, J | R |
| 6/6/2021 | | | Hou | W | 11-6 | | Matz, S | L | Matz, S | | Garcia, L | R |
| 6/8/2021 | | @ | ChA | W | 6-5 | | Ray, R | L | Mayza, T | Romano, J | Rodon, C | L |
| 6/9/2021 | | @ | ChA | W | 6-4 | | Manoah, A | R | Castro, A | Romano, J | Lynn, L | R |
| 6/10/2021 | | @ | ChA | W | 17-7 | | Ryu, H | L | Ryu, H | | Keuchel, D | L |
| 6/11/2021 | | @ | Bos | W | 7-4 | | Stripling, R | R | Stripling, R | Romano, J | Richards, G | R |
| 6/12/2021 | | @ | Bos | W | 14-8 | | Matz, S | L | Payamps, J | | Pivetta, N | R |
| 6/13/2021 | | @ | Bos | L | 4-6 | | Ray, R | L | Chatwood, T | | Perez, M | L |
| 6/14/2021 | | @ | Bos | W | 7-3 | | Manoah, A | R | Thornton, T | | Eovaldi, N | R |
| 6/15/2021 | | | NYA | W | 4-0 | | Ryu, H | L | Ryu, H | | Montgomery, J | L |
| 6/16/2021 | | | NYA | L | 4-8 | | Stripling, R | R | Romano, J | | Cole, G | R |
| 6/17/2021 | | | NYA | W | 3-2 | | Zeuch, T | R | Thornton, T | | King, M | R |
| 6/18/2021 | | @ | Bal | W | 12-6 | | Ray, R | L | Ray, R | | Eshelman, T | R |
| 6/19/2021 | | @ | Bal | W | 13-0 | | Manoah, A | R | Manoah, A | | Kremer, D | R |
| 6/20/2021 | | @ | Bal | W | 8-1 | | Ryu, H | L | Ryu, H | | Harvey, M | R |
| 6/22/2021 | | @ | Mia | W | 7-5 | | Stripling, R | R | Stripling, R | Romano, J | Alcantara, S | R |
| 6/23/2021 | | @ | Mia | W | 4-2 | | Ray, R | L | Ray, R | Romano, J | Rogers, T | L |
| 6/24/2021 | | | Bal | W | 2-0 | | Kay, A | L | Kay, A | Romano, J | Kremer, D | R |
| 6/25/2021 | | | Bal | W | 4-3 | | Manoah, A | R | Manoah, A | Mayza, T | Harvey, M | R |
| 6/26/2021 | | | Bal | W | 10-1 | | Ryu, H | L | Ryu, H | | Akin, K | L |
| 6/27/2021 | | | Bal | W | 13-7 | | Stripling, R | R | Stripling, R | | Lopez, J | R |
| 6/29/2021 | | | Sea | W | 8-1 | | Ray, R | L | Ray, R | | Flexen, C | R |
| 6/30/2021 | | | Sea | W | 4-1 | | Matz, S | L | Matz, S | Romano, J | Sheffield, J | L |
| 7/1/2021 | | | Sea | W | 9-6 | | Ryu, H | L | Ryu, H | Romano, J | Kikuchi, Y | L |
| 7/2/2021 | | | Tam | L | 1-5 | | Manoah, A | R | Manoah, A | | Patino, L | R |
| 7/3/2021 | | | Tam | W | 5-2 | | Stripling, R | R | Stripling, R | Romano, J | McClanahan, S | L |
| 7/4/2021 | | | Tam | W | 6-4 | | Ray, R | L | Ray, R | Dolis, R | Yarbrough, R | L |
| 7/6/2021 | | @ | Bal | W | 6-5 | | Matz, S | L | Saucedo, T | Romano, J | Watkins, S | R |
| 7/7/2021 | | @ | Bal | W | 10-3 | | Ryu, H | L | Kay, A | | Harvey, M | R |
| 7/9/2021 | | @ | Tam | W | 4-2 | | Manoah, A | R | Manoah, A | Romano, J | McClanahan, S | L |
| 7/10/2021 | | @ | Tam | W | 7-5 | | Stripling, R | R | Richards, T | Romano, J | Yarbrough, R | L |
| 7/11/2021 | | @ | Tam | W | 7-0 | | Ray, R | L | Ray, R | | Hill, R | L |
| 7/16/2021 | | | Tex | L | 1-6 | | Ray, R | L | Ray, R | | Lyles, J | R |
| 7/18/2021 | 1 | | Tex | L | 6-7 | 7 | Ryu, H | L | Ryu, H | | Allard, K | L |
| 7/18/2021 | 2 | | Tex | W | 4-3 | 7 | Matz, S | L | Matz, S | Romano, J | Foltynewicz, M | R |
| 7/19/2021 | | | Bos | W | 11-10 | | Stripling, R | R | Dolis, R | Romano, J | Pivetta, N | R |
| 7/21/2021 | | | Bos | L | 6-7 | | Ray, R | L | Ray, R | | Richards, G | R |
| 7/23/2021 | | @ | NYN | L | 3-4 | | Matz, S | L | Romano, J | | Megill, T | R |
| 7/24/2021 | | @ | NYN | W | 2-1 | | Ryu, H | L | Ryu, H | Dolis, R | Walker, T | R |
| 7/25/2021 | | @ | NYN | W | 8-4 | | Stripling, R | R | Stripling, R | | Hill, R | L |
| 7/26/2021 | | @ | Bos | L | 7-8 | | Hatch, T | R | Hatch, T | | Pivetta, N | R |
| 7/28/2021 | 1 | @ | Bos | W | 8-0 | 7 | Ray, R | L | Ray, R | | Richards, G | R |
| 7/28/2021 | 2 | @ | Bos | W | 8-1 | 7 | Matz, S | L | Matz, S | | Houck, T | R |
| 7/29/2021 | | @ | Bos | W | 6-3 | | Ryu, H | L | Ryu, H | Romano, J | Rodriguez, E | L |
| 7/30/2021 | | | KC | L | 3-9 | | Stripling, R | R | Stripling, R | | Lynch, D | L |
| 7/31/2021 | | | KC | L | 3-4 | | Manoah, A | R | Manoah, A | | Minor, M | L |
| 8/1/2021 | | | KC | W | 5-1 | | Berrios, J | R | Berrios, J | | Keller, B | R |
| 8/2/2021 | | | Cle | W | 4-2 | | Ray, R | L | Ray, R | Romano, J | Morgan, E | R |
| 8/3/2021 | | | Cle | L | 3-10 | | Ryu, H | L | Richards, T | | Plesac, Z | R |
| 8/4/2021 | | | Cle | W | 4-2 | | Matz, S | L | Matz, S | Romano, J | Mejia, J | R |
| 8/5/2021 | | | Cle | L | 0-3 | | Stripling, R | R | Stripling, R | | McKenzie, T | R |
| 8/6/2021 | | | Bos | L | 4-9 | | Manoah, A | R | Manoah, A | | Eovaldi, N | R |
| 8/7/2021 | 1 | | Bos | L | 1-5 | 7 | Ray, R | L | Ray, R | | Pivetta, N | R |
| 8/7/2021 | 2 | | Bos | W | 5-0 | 7 | Berrios, J | R | Berrios, J | | Houck, T | R |
| 8/8/2021 | | | Bos | W | 13-5 | | Ryu, H | L | Ryu, H | | Richards, G | R |
| 8/10/2021 | 1 | | LAA | W | 7-1 | 7 | Matz, S | L | Matz, S | | Rodriguez, C | R |
| 8/10/2021 | 2 | @ | LAA | W | 3-2 | 8 | Stripling, R | R | Thornton, T | Romano, J | Suarez, J | L |
| 8/11/2021 | | @ | LAA | W | 6-5 | | Manoah, A | R | Cimber, A | Romano, J | Bundy, D | R |
| 8/12/2021 | | @ | LAA | L | 2-10 | | Berrios, J | R | Berrios, J | | Ohtani, S | R |
| 8/13/2021 | | @ | Sea | L | 1-2 | | Ray, R | L | Snead, K | | Flexen, C | R |
| 8/14/2021 | | @ | Sea | W | 3-2 | 11 | Ryu, H | L | Romano, J | | Kikuchi, Y | L |
| 8/15/2021 | | @ | Sea | L | 4-5 | | Matz, S | L | Cimber, A | | Gilbert, L | R |
| 8/17/2021 | | @ | Was | W | 4-0 | | Manoah, A | R | Manoah, A | | Fedde, E | R |
| 8/18/2021 | | @ | Was | W | 7-2 | | Berrios, J | R | Berrios, J | | Gray, J | R |
| 8/20/2021 | | | Det | W | 8-1 | | Ray, R | L | Ray, R | | Alexander, T | L |
| 8/21/2021 | | | Det | W | 5-4 | | Ryu, H | L | Thornton, T | | Peralta, W | R |
| 8/22/2021 | | | Det | W | 7-6 | | Matz, S | L | Matz, S | Romano, J | Hutchison, D | R |
| 8/23/2021 | | | ChA | W | 6-2 | | Manoah, A | R | Thornton, T | | Lynn, L | R |
| 8/24/2021 | | | ChA | W | 6-5 | 10 | Berrios, J | R | Hand, B | | Cease, D | R |
| 8/25/2021 | | | ChA | W | 6-3 | | Ray, R | L | Ray, R | Romano, J | Giolito, L | R |
| 8/26/2021 | | | ChA | L | 0-7 | | Ryu, H | L | Ryu, H | | Rodon, C | L |
| 8/27/2021 | | @ | Det | L | 6-7 | | Matz, S | L | Matz, S | | Manning, M | R |
| 8/28/2021 | | @ | Det | W | 4-1 | | Manoah, A | R | Manoah, A | Romano, J | Urena, J | R |
| 8/29/2021 | | @ | Det | L | 0-1 | | Berrios, J | R | Berrios, J | | Boyd, M | L |
| 8/30/2021 | | | Bal | W | 4-0 | | Ray, R | L | Ray, R | | Ellis, C | R |
| 8/31/2021 | | | Bal | W | 5-2 | | Ryu, H | L | Ryu, H | Cimber, A | Akin, K | L |
| 9/1/2021 | | | Bal | W | 9-8 | 10 | Matz, S | L | Richards, T | | Harvey, M | R |
| 9/3/2021 | | | Oak | W | 4-3 | | Manoah, A | R | Manoah, A | Romano, J | Manaea, S | L |
| 9/4/2021 | | | Oak | W | 14-0 | | Berrios, J | R | Berrios, J | | Blackburn, P | R |
| 9/5/2021 | | | Oak | W | 6-5 | 11 | Ray, R | L | Richards, T | | Irvin, C | L |
| 9/6/2021 | | @ | NYA | W | 9-8 | | Ryu, H | L | Saucedo, T | Mayza, T | Taillon, J | R |
| 9/7/2021 | | @ | NYA | W | 8-2 | | Matz, S | L | Matz, S | | Cole, G | R |
| 9/8/2021 | | @ | NYA | L | 5-6 | | Manoah, A | R | Richards, T | | Gil, L | R |
| 9/9/2021 | | @ | NYA | W | 2-1 | | Berrios, J | R | Berrios, J | Cimber, A | Cortes, N | L |
| 9/10/2021 | | @ | Bal | W | 21-7 | | Ray, R | L | Ray, R | | Ellis, C | R |
| 9/11/2021 | 1 | @ | Bal | W | 1-0 | 7 | Ryu, H | L | Ryu, H | Romano, J | Kremer, D | R |
| 9/11/2021 | 2 | @ | Bal | W | 7-5 | 7 | Hatch, T | R | Castro, A | Cimber, A | Akin, K | L |
| 9/12/2021 | | @ | Bal | W | 12-11 | 11 | Matz, S | L | Romano, J | Cimber, A | Lowther, Z | L |
| 9/13/2021 | | | Tam | W | 8-5 | | Manoah, A | R | Mayza, T | Romano, J | McHugh, C | R |
| 9/14/2021 | | | Tam | L | 3-7 | | Berrios, J | R | Berrios, J | | Rasmussen, D | R |
| 9/15/2021 | | | Tam | W | 7-6 | | Ray, R | L | Ray, R | Merryweather, J | Wacha, M | R |
| 9/17/2021 | | | Min | L | 3-14 | | Ryu, H | L | Ryu, H | | Pineda, M | R |
| 9/18/2021 | | | Min | L | 5-8 | | Matz, S | L | Matz, S | | Ober, B | R |
| 9/19/2021 | | | Min | W | 6-2 | | Berrios, J | R | Berrios, J | | Farrell, L | R |
| 9/20/2021 | | @ | Tam | L | 2-3 | 11 | Ray, R | L | Richards, T | | Baz, S | R |
| 9/21/2021 | | @ | Tam | W | 4-3 | | Manoah, A | R | Manoah, A | Merryweather, J | Rasmussen, D | R |
| 9/22/2021 | | @ | Tam | L | 1-4 | | Merryweather, J | R | Cimber, A | | Patino, L | R |
| 9/23/2021 | | @ | Min | W | 5-4 | | Matz, S | L | Matz, S | Mayza, T | Pineda, M | R |
| 9/24/2021 | | @ | Min | W | 7-4 | | Berrios, J | R | Berrios, J | Romano, J | Ober, B | R |
| 9/25/2021 | | @ | Min | L | 2-3 | | Ray, R | L | Snead, K | | Gant, J | R |
| 9/26/2021 | | @ | Min | L | 1-7 | | Manoah, A | R | Manoah, A | | Jax, G | R |
| 9/28/2021 | | | NYA | W | 5-4 | | Ryu, H | L | Richards, T | | Taillon, J | R |
| 9/29/2021 | | | NYA | L | 0-13 | | Berrios, J | R | Berrios, J | | Cole, G | R |
| 9/30/2021 | | | NYA | W | 7-1 | | Ray, R | L | Ray, R | | Kluber, C | R |
| 10/1/2021 | | | Bal | W | 4-3 | 14 | Matz, S | L | Barnes, J | | Eshelman, T | R |
| 10/2/2021 | | | Bal | W | 2-1 | | Manoah, A | R | Manoah, A | Cimber, A | Means, J | L |
| 10/3/2021 | | | Bal | W | 4-0 | | Ryu, H | L | Ryu, H | Mayza, T | Zimmermann, B | L |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 4/1/2021 | | @ | NYA | W | Bichette, B | 7 | 6 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/3/2021 | | @ | NYA | W | Biggio, C | 10 | 5 | 2 | 0 | 1.000 | 2-0 | W2 | 2 |
| 4/4/2021 | | @ | NYA | L | | 6 | 11 | 2 | 1 | .667 | 2-1 | L1 | 3 |
| 4/5/2021 | | @ | Tex | W | Jansen, D | 7 | 2 | 3 | 1 | .750 | 3-1 | W1 | 4 |
| 4/6/2021 | | @ | Tex | L | | 0 | 6 | 3 | 2 | .600 | 3-2 | L1 | 5 |
| 4/7/2021 | | @ | Tex | W | Hernandez, T | 3 | 2 | 4 | 2 | .667 | 4-2 | W1 | 6 |
| 4/8/2021 | | | LAA | L | | 3 | 7 | 4 | 3 | .571 | 4-3 | L1 | 7 |
| 4/9/2021 | | | LAA | L | | 3 | 12 | 4 | 4 | .500 | 4-4 | L2 | 8 |
| 4/10/2021 | | | LAA | W | Tellez, R | 8 | 2 | 5 | 4 | .556 | 5-4 | W1 | 9 |
| 4/12/2021 | | | NYA | W | Kirk, A | 4 | 0 | 6 | 4 | .600 | 6-4 | W2 | 10 |
| 4/13/2021 | | | NYA | L | | 1 | 11 | 6 | 5 | .545 | 5-5 | L1 | 11 |
| 4/14/2021 | | | NYA | W | Guerrero, V | 5 | 1 | 7 | 5 | .583 | 5-5 | W1 | 12 |
| 4/15/2021 | | @ | KC | W | Grichuk, R | 10 | 3 | 8 | 5 | .615 | 6-4 | W2 | 13 |
| 4/17/2021 | 1 | @ | KC | W | Guerrero, V | 3 | 2 | 9 | 5 | .643 | 6-4 | W3 | 14 |
| 4/17/2021 | 2 | @ | KC | W | Bichette, B | 6 | 4 | 10 | 5 | .667 | 7-3 | W4 | 15 |
| 4/18/2021 | | @ | KC | W | Semien, M | 6 | 3 | 11 | 5 | .688 | 7-3 | W5 | 16 |
| 4/20/2021 | | @ | Bos | L | | 2 | 3 | 11 | 6 | .647 | 7-3 | L1 | 17 |
| 4/21/2021 | | @ | Bos | W | Grichuk, R | 5 | 3 | 12 | 6 | .667 | 8-2 | W1 | 18 |
| 4/23/2021 | | @ | Tam | W | Bichette, B | 4 | 2 | 13 | 6 | .684 | 8-2 | W2 | 19 |
| 4/24/2021 | | @ | Tam | W | Grichuk, R | 9 | 7 | 14 | 6 | .700 | 8-2 | W3 | 20 |
| 4/25/2021 | | @ | Tam | W | Guerrero, V | 4 | 3 | 15 | 6 | .714 | 9-1 | W4 | 21 |
| 4/27/2021 | | | Was | L | | 7 | 8 | 15 | 7 | .682 | 8-2 | L1 | 22 |
| 4/28/2021 | | | Was | W | Springer, G | 17 | 5 | 16 | 7 | .696 | 8-2 | W1 | 23 |
| 4/30/2021 | | | Atl | W | Semien, M | 14 | 4 | 17 | 7 | .708 | 8-2 | W2 | 24 |
| 5/1/2021 | | | Atl | L | | 4 | 12 | 17 | 8 | .680 | 7-3 | L1 | 25 |
| 5/2/2021 | | | Atl | L | | 3 | 4 | 17 | 9 | .654 | 6-4 | L2 | 26 |
| 5/3/2021 | | @ | Oak | W | Semien, M | 2 | 1 | 18 | 9 | .667 | 7-3 | W1 | 27 |
| 5/4/2021 | | @ | Oak | W | Hernandez, T | 7 | 2 | 19 | 9 | .679 | 7-3 | W2 | 28 |
| 5/5/2021 | | @ | Oak | W | Bichette, B | 4 | 1 | 20 | 9 | .690 | 7-3 | W3 | 29 |
| 5/6/2021 | | @ | Oak | L | | 6 | 21 | 20 | 10 | .667 | 6-4 | L1 | 30 |
| 5/7/2021 | | @ | Hou | L | | 2 | 3 | 20 | 11 | .645 | 5-5 | L2 | 31 |
| 5/8/2021 | | @ | Hou | W | Grichuk, R | 7 | 3 | 21 | 11 | .656 | 6-4 | W1 | 32 |
| 5/9/2021 | | @ | Hou | L | | 4 | 5 | 21 | 12 | .636 | 5-5 | L1 | 33 |
| 5/11/2021 | | @ | Atl | W | Gurriel, L | 6 | 3 | 22 | 12 | .647 | 5-5 | W1 | 34 |
| 5/12/2021 | | @ | Atl | W | Jansen, D | 4 | 3 | 23 | 12 | .657 | 6-4 | W2 | 35 |
| 5/13/2021 | | @ | Atl | W | Hernandez, T | 3 | 2 | 24 | 12 | .667 | 7-3 | W3 | 36 |
| 5/14/2021 | | | Phi | W | Semien, M | 10 | 2 | 25 | 12 | .676 | 7-3 | W4 | 37 |
| 5/15/2021 | | | Phi | W | Grichuk, R | 5 | 3 | 26 | 12 | .684 | 7-3 | W5 | 38 |
| 5/16/2021 | | | Phi | L | | 1 | 4 | 26 | 13 | .667 | 6-4 | L1 | 39 |
| 5/18/2021 | | | Bos | W | Gurriel, L | 4 | 2 | 27 | 13 | .675 | 7-3 | W1 | 40 |
| 5/19/2021 | | | Bos | W | Hernandez, T | 9 | 2 | 28 | 13 | .683 | 8-2 | W2 | 41 |
| 5/20/2021 | | | Bos | L | | 5 | 8 | 28 | 14 | .667 | 7-3 | L1 | 42 |
| 5/21/2021 | | | Tam | L | | 9 | 10 | 28 | 15 | .651 | 7-3 | L2 | 43 |
| 5/22/2021 | | | Tam | W | Guerrero, V | 5 | 3 | 29 | 15 | .659 | 7-3 | W1 | 44 |
| 5/23/2021 | | | Tam | L | | 2 | 10 | 29 | 16 | .644 | 6-4 | L1 | 45 |
| 5/24/2021 | | | Tam | L | | 0 | 2 | 29 | 17 | .630 | 5-5 | L2 | 46 |
| 5/25/2021 | | @ | NYA | L | | 3 | 4 | 29 | 18 | .617 | 4-6 | L3 | 47 |
| 5/27/2021 | 1 | @ | NYA | W | Hernandez, T | 6 | 2 | 30 | 18 | .625 | 4-6 | W1 | 48 |
| 5/27/2021 | 2 | @ | NYA | L | | 0 | 1 | 30 | 19 | .612 | 4-6 | L1 | 49 |
| 5/28/2021 | | @ | Cle | L | | 3 | 6 | 30 | 20 | .600 | 3-7 | L2 | 50 |
| 5/30/2021 | 1 | @ | Cle | W | Tellez, R | 7 | 5 | 31 | 20 | .608 | 3-7 | W1 | 51 |
| 5/30/2021 | 2 | @ | Cle | W | Jansen, D | 2 | 1 | 32 | 20 | .615 | 4-6 | W2 | 52 |
| 6/1/2021 | | | Mia | W | | 7 | 4 | 33 | 20 | .623 | 5-5 | W3 | 53 |
| 6/2/2021 | | | Mia | W | Semien, M | 6 | 0 | 34 | 20 | .630 | 5-5 | W4 | 54 |
| 6/4/2021 | | | Hou | L | | 4 | 5 | 34 | 21 | .618 | 5-5 | L1 | 55 |
| 6/5/2021 | | | Hou | L | | 7 | 11 | 34 | 22 | .607 | 5-5 | L2 | 56 |
| 6/6/2021 | | | Hou | W | Bichette, B | 11 | 6 | 35 | 22 | .614 | 6-4 | W1 | 57 |
| 6/8/2021 | | @ | ChA | W | Semien, M | 6 | 5 | 36 | 22 | .621 | 6-4 | W2 | 58 |
| 6/9/2021 | | @ | ChA | W | Panik, J | 6 | 4 | 37 | 22 | .627 | 7-3 | W3 | 59 |
| 6/10/2021 | | @ | ChA | W | Guerrero, V | 17 | 7 | 38 | 22 | .633 | 8-2 | W4 | 60 |
| 6/11/2021 | | @ | Bos | W | Bichette, B | 7 | 4 | 39 | 22 | .639 | 8-2 | W5 | 61 |
| 6/12/2021 | | @ | Bos | W | Hernandez, T | 14 | 8 | 40 | 22 | .645 | 8-2 | W6 | 62 |
| 6/13/2021 | | @ | Bos | L | | 4 | 6 | 40 | 23 | .635 | 7-3 | L1 | 63 |
| 6/14/2021 | | @ | Bos | W | Guerrero, V | 7 | 3 | 41 | 23 | .641 | 7-3 | W1 | 64 |
| 6/15/2021 | | | NYA | W | Bichette, B | 4 | 0 | 42 | 23 | .646 | 8-2 | W2 | 65 |
| 6/16/2021 | | | NYA | L | | 4 | 8 | 42 | 24 | .636 | 8-2 | L1 | 66 |
| 6/17/2021 | | | NYA | W | Grichuk, R | 3 | 2 | 43 | 24 | .642 | 8-2 | W1 | 67 |
| 6/18/2021 | | @ | Bal | W | Guerrero, V | 12 | 6 | 44 | 24 | .647 | 8-2 | W2 | 68 |
| 6/19/2021 | | @ | Bal | W | Espinal, S | 13 | 0 | 45 | 24 | .652 | 8-2 | W3 | 69 |
| 6/20/2021 | | @ | Bal | W | Hernandez, T | 8 | 1 | 46 | 24 | .657 | 8-2 | W4 | 70 |
| 6/22/2021 | | @ | Mia | W | Bichette, B | 7 | 5 | 47 | 24 | .662 | 8-2 | W5 | 71 |
| 6/23/2021 | | @ | Mia | W | Adams, R | 4 | 2 | 48 | 24 | .667 | 8-2 | W6 | 72 |
| 6/24/2021 | | | Bal | W | Semien, M | 2 | 0 | 49 | 24 | .671 | 9-1 | W7 | 73 |
| 6/25/2021 | | | Bal | W | Grichuk, R | 4 | 3 | 50 | 24 | .676 | 9-1 | W8 | 74 |
| 6/26/2021 | | | Bal | W | Bichette, B | 10 | 1 | 51 | 24 | .680 | 9-1 | W9 | 75 |
| 6/27/2021 | | | Bal | W | McGuire, R | 13 | 7 | 52 | 24 | .684 | 10-0 | W10 | 76 |
| 6/29/2021 | | | Sea | W | Guerrero, V | 8 | 1 | 53 | 24 | .688 | 10-0 | W11 | 77 |
| 6/30/2021 | | | Sea | W | Bichette, B | 4 | 1 | 54 | 24 | .692 | 10-0 | W12 | 78 |
| 7/1/2021 | | | Sea | W | Gurriel, L | 9 | 6 | 55 | 24 | .696 | 10-0 | W13 | 79 |
| 7/2/2021 | | | Tam | L | | 1 | 5 | 55 | 25 | .688 | 9-1 | L1 | 80 |
| 7/3/2021 | | | Tam | W | McGuire, R | 5 | 2 | 56 | 25 | .691 | 9-1 | W1 | 81 |
| 7/4/2021 | | | Tam | W | Semien, M | 6 | 4 | 57 | 25 | .695 | 9-1 | W2 | 82 |
| 7/6/2021 | | @ | Bal | W | Guerrero, V | 6 | 5 | 58 | 25 | .699 | 9-1 | W3 | 83 |
| 7/7/2021 | | @ | Bal | W | Guerrero, V | 10 | 3 | 59 | 25 | .702 | 9-1 | W4 | 84 |
| 7/9/2021 | | @ | Tam | W | | 4 | 2 | 60 | 25 | .706 | 9-1 | W5 | 85 |
| 7/10/2021 | | @ | Tam | W | Gurriel, L | 7 | 5 | 61 | 25 | .709 | 9-1 | W6 | 86 |
| 7/11/2021 | | @ | Tam | W | Espinal, S | 7 | 0 | 62 | 25 | .713 | 9-1 | W7 | 87 |
| 7/16/2021 | | | Tex | L | | 1 | 6 | 62 | 26 | .705 | 8-2 | L1 | 88 |
| 7/18/2021 | 1 | | Tex | L | | 6 | 7 | 62 | 27 | .697 | 7-3 | L2 | 89 |
| 7/18/2021 | 2 | | Tex | W | Gurriel, L | 4 | 3 | 63 | 27 | .700 | 8-2 | W1 | 90 |
| 7/19/2021 | | | Bos | W | Hernandez, T | 11 | 10 | 64 | 27 | .703 | 8-2 | W2 | 91 |
| 7/21/2021 | | | Bos | L | | 6 | 7 | 64 | 28 | .696 | 7-3 | L1 | 92 |
| 7/23/2021 | | @ | NYN | L | | 3 | 4 | 64 | 29 | .688 | 6-4 | L2 | 93 |
| 7/24/2021 | | @ | NYN | W | Bichette, B | 2 | 1 | 65 | 29 | .691 | 6-4 | W1 | 94 |
| 7/25/2021 | | @ | NYN | W | Bichette, B | 8 | 4 | 66 | 29 | .695 | 6-4 | W2 | 95 |
| 7/26/2021 | | @ | Bos | L | | 7 | 8 | 66 | 30 | .688 | 5-5 | L1 | 96 |
| 7/28/2021 | 1 | @ | Bos | W | Semien, M | 8 | 0 | 67 | 30 | .691 | 5-5 | W1 | 97 |
| 7/28/2021 | 2 | @ | Bos | W | Hernandez, T | 8 | 1 | 68 | 30 | .694 | 6-4 | W2 | 98 |
| 7/29/2021 | | @ | Bos | W | Hernandez, T | 6 | 3 | 69 | 30 | .697 | 7-3 | W3 | 99 |
| 7/30/2021 | | | KC | L | | 3 | 9 | 69 | 31 | .690 | 6-4 | L1 | 100 |
| 7/31/2021 | | | KC | L | | 3 | 4 | 69 | 32 | .683 | 5-5 | L2 | 101 |
| 8/1/2021 | | | KC | W | Springer, G | 5 | 1 | 70 | 32 | .686 | 6-4 | W1 | 102 |
| 8/2/2021 | | | Cle | W | Springer, G | 4 | 2 | 71 | 32 | .689 | 7-3 | W2 | 103 |
| 8/3/2021 | | | Cle | L | | 3 | 10 | 71 | 33 | .683 | 6-4 | L1 | 104 |
| 8/4/2021 | | | Cle | W | Valera, B | 4 | 2 | 72 | 33 | .686 | 6-4 | W1 | 105 |
| 8/5/2021 | | | Cle | L | | 0 | 3 | 72 | 34 | .679 | 6-4 | L1 | 106 |
| 8/6/2021 | | | Bos | L | | 4 | 9 | 72 | 35 | .673 | 5-5 | L2 | 107 |
| 8/7/2021 | 1 | | Bos | L | | 1 | 5 | 72 | 36 | .667 | 4-6 | L3 | 108 |
| 8/7/2021 | 2 | | Bos | W | Grichuk, R | 5 | 0 | 73 | 36 | .670 | 4-6 | W1 | 109 |
| 8/8/2021 | | | Bos | W | Guerrero, V | 13 | 5 | 74 | 36 | .673 | 5-5 | W2 | 110 |
| 8/10/2021 | 1 | | LAA | W | Hernandez, T | 7 | 1 | 76 | 36 | .679 | 6-4 | W4 | 112 |
| 8/10/2021 | 2 | @ | LAA | W | Semien, M | 3 | 2 | 75 | 36 | .676 | 6-4 | W3 | 111 |
| 8/11/2021 | | @ | LAA | W | Springer, G | 6 | 5 | 77 | 36 | .681 | 6-4 | W5 | 113 |
| 8/12/2021 | | @ | LAA | L | | 2 | 10 | 77 | 37 | .675 | 6-4 | L1 | 114 |
| 8/13/2021 | | @ | Sea | L | | 1 | 2 | 77 | 38 | .670 | 5-5 | L2 | 115 |
| 8/14/2021 | | @ | Sea | W | Gurriel, L | 3 | 2 | 78 | 38 | .672 | 6-4 | W1 | 116 |
| 8/15/2021 | | @ | Sea | L | | 4 | 5 | 78 | 39 | .667 | 6-4 | L1 | 117 |
| 8/17/2021 | | @ | Was | W | Grichuk, R | 4 | 0 | 79 | 39 | .669 | 7-3 | W1 | 118 |
| 8/18/2021 | | @ | Was | W | Bichette, B | 7 | 2 | 80 | 39 | .672 | 7-3 | W2 | 119 |
| 8/20/2021 | | | Det | W | Semien, M | 8 | 1 | 81 | 39 | .675 | 7-3 | W3 | 120 |
| 8/21/2021 | | | Det | W | Dickerson, C | 5 | 4 | 82 | 39 | .678 | 7-3 | W4 | 121 |
| 8/22/2021 | | | Det | W | | 7 | 6 | 83 | 39 | .680 | 7-3 | W5 | 122 |
| 8/23/2021 | | | ChA | W | Hernandez, T | 6 | 2 | 84 | 39 | .683 | 7-3 | W6 | 123 |
| 8/24/2021 | | | ChA | W | Hernandez, T | 6 | 5 | 85 | 39 | .685 | 8-2 | W7 | 124 |
| 8/25/2021 | | | ChA | W | Grichuk, R | 6 | 3 | 86 | 39 | .688 | 9-1 | W8 | 125 |
| 8/26/2021 | | | ChA | L | | 0 | 7 | 86 | 40 | .683 | 8-2 | L1 | 126 |
| 8/27/2021 | | @ | Det | L | | 6 | 7 | 86 | 41 | .677 | 8-2 | L2 | 127 |
| 8/28/2021 | | @ | Det | W | Dickerson, C | 4 | 1 | 87 | 41 | .680 | 8-2 | W1 | 128 |
| 8/29/2021 | | @ | Det | L | | 0 | 1 | 87 | 42 | .674 | 7-3 | L1 | 129 |
| 8/30/2021 | | | Bal | W | Springer, G | 4 | 0 | 88 | 42 | .677 | 7-3 | W1 | 130 |
| 8/31/2021 | | | Bal | W | Grichuk, R | 5 | 2 | 89 | 42 | .679 | 7-3 | W2 | 131 |
| 9/1/2021 | | | Bal | W | Smith, K | 9 | 8 | 90 | 42 | .682 | 7-3 | W3 | 132 |
| 9/3/2021 | | | Oak | W | Guerrero, V | 4 | 3 | 91 | 42 | .684 | 7-3 | W4 | 133 |
| 9/4/2021 | | | Oak | W | Hernandez, T | 14 | 0 | 92 | 42 | .687 | 7-3 | W5 | 134 |
| 9/5/2021 | | | Oak | W | Guerrero, V | 6 | 5 | 93 | 42 | .689 | 7-3 | W6 | 135 |
| 9/6/2021 | | @ | NYA | W | Gurriel, L | 9 | 8 | 94 | 42 | .691 | 8-2 | W7 | 136 |
| 9/7/2021 | | @ | NYA | W | Hernandez, T | 8 | 2 | 95 | 42 | .693 | 9-1 | W8 | 137 |
| 9/8/2021 | | @ | NYA | L | | 5 | 6 | 95 | 43 | .688 | 8-2 | L1 | 138 |
| 9/9/2021 | | @ | NYA | W | | 2 | 1 | 96 | 43 | .691 | 9-1 | W1 | 139 |
| 9/10/2021 | | @ | Bal | W | Semien, M | 21 | 7 | 97 | 43 | .693 | 9-1 | W2 | 140 |
| 9/11/2021 | 1 | @ | Bal | W | Gurriel, L | 1 | 0 | 98 | 43 | .695 | 9-1 | W3 | 141 |
| 9/11/2021 | 2 | @ | Bal | W | Bichette, B | 7 | 5 | 99 | 43 | .697 | 9-1 | W4 | 142 |
| 9/12/2021 | | @ | Bal | W | Bichette, B | 12 | 11 | 100 | 43 | .699 | 9-1 | W5 | 143 |
| 9/13/2021 | | | Tam | W | Semien, M | 8 | 5 | 101 | 43 | .701 | 9-1 | W6 | 144 |
| 9/14/2021 | | | Tam | L | | 3 | 7 | 101 | 44 | .697 | 8-2 | L1 | 145 |
| 9/15/2021 | | | Tam | W | Bichette, B | 7 | 6 | 102 | 44 | .699 | 8-2 | W1 | 146 |
| 9/17/2021 | | | Min | L | | 3 | 14 | 102 | 45 | .694 | 7-3 | L1 | 147 |
| 9/18/2021 | | | Min | L | | 5 | 8 | 102 | 46 | .689 | 7-3 | L2 | 148 |
| 9/19/2021 | | | Min | W | Bichette, B | 6 | 2 | 103 | 46 | .691 | 7-3 | W1 | 149 |
| 9/20/2021 | | @ | Tam | L | | 2 | 3 | 103 | 47 | .687 | 6-4 | L1 | 150 |
| 9/21/2021 | | @ | Tam | W | Semien, M | 4 | 3 | 104 | 47 | .689 | 6-4 | W1 | 151 |
| 9/22/2021 | | @ | Tam | L | | 1 | 4 | 104 | 48 | .684 | 5-5 | L1 | 152 |
| 9/23/2021 | | @ | Min | W | Guerrero, V | 5 | 4 | 105 | 48 | .686 | 5-5 | W1 | 153 |
| 9/24/2021 | | @ | Min | W | Dickerson, C | 7 | 4 | 106 | 48 | .688 | 5-5 | W2 | 154 |
| 9/25/2021 | | @ | Min | L | | 2 | 3 | 106 | 49 | .684 | 5-5 | L1 | 155 |
| 9/26/2021 | | @ | Min | L | | 1 | 7 | 106 | 50 | .679 | 4-6 | L2 | 156 |
| 9/28/2021 | | | NYA | W | Semien, M | 5 | 4 | 107 | 50 | .682 | 5-5 | W1 | 157 |
| 9/29/2021 | | | NYA | L | | 0 | 13 | 107 | 51 | .677 | 5-5 | L1 | 158 |
| 9/30/2021 | | | NYA | W | Springer, G | 7 | 1 | 108 | 51 | .679 | 5-5 | W1 | 159 |
| 10/1/2021 | | | Bal | W | Kirk, A | 4 | 3 | 109 | 51 | .681 | 6-4 | W2 | 160 |
| 10/2/2021 | | | Bal | W | Guerrero, V | 2 | 1 | 110 | 51 | .683 | 6-4 | W3 | 161 |
| 10/3/2021 | | | Bal | W | Jansen, D | 4 | 0 | 111 | 51 | .685 | 7-3 | W4 | 162 |