Team game results - 2021 Cleveland
Regular season
| Primary |
| Date | # | | Opp | | Score | Inn | Starter | T | W/L | Save | Versus | T |
| 9/29/2014 | | | Det | L | 2-5 | | | R | | | | R |
| 4/1/2021 | | @ | Det | W | 9-5 | | Bieber, S | R | Bieber, S | | Boyd, M | L |
| 4/3/2021 | | @ | Det | L | 5-6 | 11 | Plesac, Z | R | Wittgren, N | | Teheran, J | R |
| 4/4/2021 | | @ | Det | W | 9-6 | 10 | Civale, A | R | Quantrill, C | | Skubal, T | L |
| 4/5/2021 | | | KC | L | 1-2 | | Allen, L | L | Allen, L | | Duffy, D | L |
| 4/7/2021 | | | KC | W | 8-1 | | Bieber, S | R | Bieber, S | | Junis, J | R |
| 4/9/2021 | | | Det | W | 11-4 | | Plesac, Z | R | Plesac, Z | | Holland, D | L |
| 4/10/2021 | | | Det | W | 5-2 | | Civale, A | R | Civale, A | Clase, E | Skubal, T | L |
| 4/11/2021 | | | Det | W | 9-7 | | Allen, L | L | Perez, O | Clase, E | Urena, J | R |
| 4/12/2021 | | @ | ChA | L | 5-12 | | McKenzie, T | R | Shaw, B | | Keuchel, D | L |
| 4/13/2021 | | @ | ChA | W | 2-1 | | Bieber, S | R | Bieber, S | Clase, E | Giolito, L | R |
| 4/14/2021 | | @ | ChA | L | 3-10 | | Plesac, Z | R | Plesac, Z | | Rodon, C | L |
| 4/15/2021 | | @ | ChA | W | 2-0 | | Civale, A | R | Civale, A | Clase, E | Lynn, L | R |
| 4/16/2021 | | @ | Cin | L | 5-6 | | Allen, L | L | Allen, L | | Hoffman, J | R |
| 4/17/2021 | | @ | Cin | L | 6-13 | | McKenzie, T | R | McKenzie, T | | Gray, S | R |
| 4/18/2021 | | @ | Cin | W | 3-2 | | Bieber, S | R | Clase, E | Stephan, T | Miley, W | L |
| 4/20/2021 | | | ChA | L | 2-7 | | Plesac, Z | R | Plesac, Z | | Rodon, C | L |
| 4/22/2021 | | | NYA | W | 13-1 | | Civale, A | R | Civale, A | | German, D | R |
| 4/23/2021 | | | NYA | L | 1-5 | | Allen, L | L | Allen, L | | Montgomery, J | L |
| 4/24/2021 | | | NYA | L | 2-3 | | Bieber, S | R | Bieber, S | | Cole, G | R |
| 4/25/2021 | | | NYA | W | 6-3 | | McKenzie, T | R | Maton, P | Clase, E | Taillon, J | R |
| 4/26/2021 | | | Min | W | 6-3 | 10 | Plesac, Z | R | Stephan, T | | Berrios, J | R |
| 4/27/2021 | | | Min | L | 3-5 | | Civale, A | R | Civale, A | | Maeda, K | R |
| 4/28/2021 | | | Min | W | 11-8 | | Allen, L | L | Stephan, T | Clase, E | Happ, J | L |
| 4/30/2021 | | @ | ChA | W | 9-3 | | Bieber, S | R | Bieber, S | | Keuchel, D | L |
| 5/1/2021 | | @ | ChA | L | 2-7 | | McKenzie, T | R | Quantrill, C | | Lynn, L | R |
| 5/2/2021 | | @ | ChA | W | 4-1 | | Plesac, Z | R | Plesac, Z | Clase, E | Giolito, L | R |
| 5/3/2021 | | @ | KC | W | 6-5 | | Civale, A | R | Civale, A | Clase, E | Lynch, D | L |
| 5/4/2021 | | @ | KC | W | 6-5 | 11 | Maton, P | R | Wittgren, N | Stephan, T | Minor, M | L |
| 5/5/2021 | | @ | KC | L | 3-9 | | Bieber, S | R | Bieber, S | | Singer, B | R |
| 5/6/2021 | | @ | KC | W | 6-2 | | McKenzie, T | R | McKenzie, T | | Duffy, D | L |
| 5/7/2021 | | | Cin | W | 9-4 | | Plesac, Z | R | Plesac, Z | | Miley, W | L |
| 5/8/2021 | | | Cin | L | 4-5 | | Civale, A | R | Civale, A | | Castillo, L | R |
| 5/11/2021 | | | ChN | W | 4-0 | | Bieber, S | R | Bieber, S | Clase, E | Alzolay, A | R |
| 5/12/2021 | | | ChN | L | 2-3 | | Hentges, S | L | Hentges, S | | Davies, Z | R |
| 5/13/2021 | | @ | Sea | W | 5-4 | 10 | Plesac, Z | R | Wittgren, N | Clase, E | Gilbert, L | R |
| 5/14/2021 | | @ | Sea | L | 1-7 | | Civale, A | R | Civale, A | | Flexen, C | R |
| 5/15/2021 | | @ | Sea | W | 3-2 | | McKenzie, T | R | Sandlin, N | Clase, E | Sheffield, J | L |
| 5/16/2021 | | @ | Sea | L | 3-4 | | Bieber, S | R | Wittgren, N | | Dugger, R | R |
| 5/17/2021 | | @ | LAA | L | 0-5 | | Hentges, S | L | Quantrill, C | | Sandoval, P | L |
| 5/18/2021 | | @ | LAA | W | 3-0 | | Plesac, Z | R | Plesac, Z | Clase, E | Heaney, A | L |
| 5/19/2021 | | @ | LAA | L | 0-3 | | Civale, A | R | Civale, A | | Ohtani, S | R |
| 5/21/2021 | | | Min | L | 2-6 | | McKenzie, T | R | McKenzie, T | | Dobnak, R | R |
| 5/22/2021 | | | Min | W | 6-2 | | Bieber, S | R | Bieber, S | | Maeda, K | R |
| 5/23/2021 | | | Min | W | 3-2 | | Plesac, Z | R | Clase, E | | Happ, J | L |
| 5/24/2021 | | @ | Det | W | 10-9 | 12 | Hentges, S | L | Clase, E | Shaw, B | Turnbull, S | R |
| 5/25/2021 | | @ | Det | W | 10-6 | | Civale, A | R | Civale, A | Maton, P | Skubal, T | L |
| 5/26/2021 | | @ | Det | L | 3-14 | | McKenzie, T | R | McKenzie, T | | Urena, J | R |
| 5/27/2021 | | @ | Det | L | 1-3 | | Bieber, S | R | Bieber, S | | Boyd, M | L |
| 5/28/2021 | | | Tor | W | 6-3 | | Morgan, E | R | Morgan, E | Karinchak, J | Ryu, H | L |
| 5/30/2021 | 1 | | Tor | L | 5-7 | 7 | Civale, A | R | Civale, A | | Stripling, R | R |
| 5/30/2021 | 2 | | Tor | L | 1-2 | 7 | Hentges, S | L | Hentges, S | | Matz, S | L |
| 5/31/2021 | 1 | | ChA | L | 0-5 | 7 | McKenzie, T | R | McKenzie, T | | Rodon, C | L |
| 5/31/2021 | 2 | | ChA | W | 1-0 | 7 | Quantrill, C | R | Quantrill, C | Clase, E | Lambert, J | R |
| 6/1/2021 | | | ChA | W | 10-5 | | Bieber, S | R | Bieber, S | | Cease, D | R |
| 6/4/2021 | | @ | Bal | L | 5-8 | | Mejia, J | R | Mejia, J | | Akin, K | L |
| 6/5/2021 | | @ | Bal | L | 4-6 | | Civale, A | R | Civale, A | | Means, J | L |
| 6/6/2021 | | @ | Bal | L | 3-8 | | Quantrill, C | R | Quantrill, C | | Lopez, J | R |
| 6/8/2021 | | @ | StL | L | 0-3 | | Bieber, S | R | Bieber, S | | Martinez, C | R |
| 6/9/2021 | | @ | StL | L | 3-6 | | Mejia, J | R | Maton, P | | Wainwright, A | R |
| 6/11/2021 | | | Sea | W | 9-6 | | Civale, A | R | Civale, A | Clase, E | Dunn, J | R |
| 6/12/2021 | | | Sea | W | 3-2 | 10 | McKenzie, T | R | Clase, E | | Kikuchi, Y | L |
| 6/13/2021 | | | Sea | W | 6-2 | | Bieber, S | R | Bieber, S | | Gilbert, L | R |
| 6/14/2021 | | | Bal | L | 3-10 | | Mejia, J | R | Mejia, J | | Kremer, D | R |
| 6/15/2021 | | | Bal | W | 4-3 | | Quantrill, C | R | Quantrill, C | Clase, E | Harvey, M | R |
| 6/16/2021 | | | Bal | L | 1-4 | | Civale, A | R | Civale, A | | Akin, K | L |
| 6/17/2021 | | | Bal | W | 8-3 | | Morgan, E | R | Morgan, E | | Lopez, J | R |
| 6/18/2021 | | @ | Pit | L | 6-8 | | Mejia, J | R | Sandlin, N | | Kuhl, C | R |
| 6/19/2021 | | @ | Pit | W | 7-2 | | Quantrill, C | R | Quantrill, C | | Crowe, W | R |
| 6/20/2021 | | @ | Pit | W | 4-1 | | Hentges, S | L | Hentges, S | Karinchak, J | Brubaker, J | R |
| 6/21/2021 | | @ | ChN | L | 2-5 | | Civale, A | R | Civale, A | | Alzolay, A | R |
| 6/22/2021 | | @ | ChN | W | 6-5 | 10 | Morgan, E | R | Karinchak, J | Wittgren, N | Hendricks, K | R |
| 6/24/2021 | | @ | Min | L | 1-5 | | Mejia, J | R | Mejia, J | | Berrios, J | R |
| 6/25/2021 | | @ | Min | W | 3-0 | | Quantrill, C | R | Quantrill, C | Clase, E | Coulombe, D | L |
| 6/27/2021 | | @ | Min | L | 1-3 | | Hentges, S | L | Hentges, S | | Happ, J | L |
| 6/28/2021 | | | Det | W | 7-1 | | Morgan, E | R | Morgan, E | | Manning, M | R |
| 6/30/2021 | 1 | | Det | W | 3-2 | 7 | Quantrill, C | R | Shaw, B | | Urena, J | R |
| 6/30/2021 | 2 | | Det | L | 3-7 | 7 | Allen, L | L | Allen, L | | Peralta, W | R |
| 7/1/2021 | | | Hou | L | 2-3 | 11 | Mejia, J | R | Maton, P | | Valdez, F | L |
| 7/2/2021 | | | Hou | L | 3-9 | | Hentges, S | L | Hentges, S | | McCullers, L | R |
| 7/3/2021 | | | Hou | W | 6-1 | | Morgan, E | R | Morgan, E | | Odorizzi, J | R |
| 7/4/2021 | | | Hou | W | 3-1 | | Quantrill, C | R | Quantrill, C | Clase, E | Greinke, Z | R |
| 7/5/2021 | | @ | Tam | L | 4-7 | | Allen, L | L | Maton, P | | Hill, R | L |
| 7/7/2021 | 1 | @ | Tam | L | 3-4 | 7 | Mejia, J | R | Mejia, J | | Wacha, M | R |
| 7/7/2021 | 2 | @ | Tam | L | 1-3 | 7 | Hentges, S | L | Hentges, S | | McHugh, C | R |
| 7/8/2021 | | | KC | W | 4-1 | | Plesac, Z | R | Plesac, Z | Clase, E | Duffy, D | L |
| 7/9/2021 | | | KC | W | 8-3 | | McKenzie, T | R | McKenzie, T | | Keller, B | R |
| 7/10/2021 | | | KC | W | 4-0 | | Quantrill, C | R | Quantrill, C | | Minor, M | L |
| 7/16/2021 | | @ | Oak | L | 2-9 | | Morgan, E | R | Morgan, E | | Manaea, S | L |
| 7/17/2021 | | @ | Oak | W | 3-2 | 10 | Quantrill, C | R | Stephan, T | Clase, E | Montas, F | R |
| 7/18/2021 | | @ | Oak | L | 4-7 | | Plesac, Z | R | Plesac, Z | | Bassitt, C | R |
| 7/19/2021 | | @ | Hou | W | 3-2 | | Mejia, J | R | Shaw, B | Clase, E | Greinke, Z | R |
| 7/20/2021 | | @ | Hou | L | 2-3 | | McKenzie, T | R | Parker, B | | Garcia, L | R |
| 7/21/2021 | | @ | Hou | W | 3-0 | | Morgan, E | R | Stephan, T | Karinchak, J | McCullers, L | R |
| 7/22/2021 | | | Tam | L | 6-9 | | Quantrill, C | R | Shaw, B | | Patino, L | R |
| 7/23/2021 | | | Tam | L | 1-16 | | Plesac, Z | R | Plesac, Z | | Fleming, J | L |
| 7/24/2021 | | | Tam | L | 2-3 | | Mejia, J | R | Mejia, J | | Rasmussen, D | R |
| 7/25/2021 | | | Tam | W | 12-10 | 11 | McKenzie, T | R | Karinchak, J | | Yarbrough, R | L |
| 7/27/2021 | | | StL | W | 4-3 | | Quantrill, C | R | Quantrill, C | Clase, E | Wainwright, A | R |
| 7/28/2021 | | | StL | W | 4-2 | | Plesac, Z | R | Plesac, Z | Clase, E | Kim, K | L |
| 7/30/2021 | | @ | ChA | W | 3-0 | | Mejia, J | R | Mejia, J | Clase, E | Lynn, L | R |
| 7/31/2021 | | @ | ChA | W | 3-0 | | McKenzie, T | R | McKenzie, T | Clase, E | Keuchel, D | L |
| 8/1/2021 | | @ | ChA | W | 12-8 | | Quantrill, C | R | Parker, B | | Lambert, J | R |
| 8/2/2021 | | @ | Tor | L | 2-4 | | Morgan, E | R | Morgan, E | | Ray, R | L |
| 8/3/2021 | | @ | Tor | W | 10-3 | | Plesac, Z | R | Sandlin, N | | Ryu, H | L |
| 8/4/2021 | | @ | Tor | L | 2-4 | | Mejia, J | R | Mejia, J | | Matz, S | L |
| 8/5/2021 | | @ | Tor | W | 3-0 | | McKenzie, T | R | McKenzie, T | Clase, E | Stripling, R | R |
| 8/6/2021 | | | Det | L | 3-7 | | Quantrill, C | R | Quantrill, C | | Manning, M | R |
| 8/7/2021 | | | Det | W | 2-1 | 10 | Morgan, E | R | Karinchak, J | | Alexander, T | L |
| 8/8/2021 | | | Det | W | 11-2 | | Plesac, Z | R | Plesac, Z | | Peralta, W | R |
| 8/9/2021 | | | Cin | L | 3-4 | | Hentges, S | L | Hentges, S | | Castillo, L | R |
| 8/10/2021 | | | Oak | W | 4-2 | | McKenzie, T | R | McKenzie, T | Clase, E | Manaea, S | L |
| 8/11/2021 | | | Oak | W | 4-0 | | Quantrill, C | R | Quantrill, C | | Montas, F | R |
| 8/12/2021 | | | Oak | W | 4-3 | | Morgan, E | R | Karinchak, J | | Bassitt, C | R |
| 8/13/2021 | | @ | Det | L | 1-6 | | Plesac, Z | R | Plesac, Z | | Alexander, T | L |
| 8/14/2021 | | @ | Det | W | 10-7 | | Hentges, S | L | Hentges, S | Clase, E | Peralta, W | R |
| 8/15/2021 | | @ | Det | W | 9-4 | | McKenzie, T | R | McKenzie, T | | Hutchison, D | R |
| 8/16/2021 | | @ | Min | L | 8-12 | | Quantrill, C | R | Stephan, T | | Jax, G | R |
| 8/17/2021 | | @ | Min | W | 5-2 | | Morgan, E | R | Morgan, E | Karinchak, J | Ober, B | R |
| 8/18/2021 | | @ | Min | W | 4-0 | | Plesac, Z | R | Plesac, Z | | Thorpe, L | L |
| 8/20/2021 | | | LAA | W | 6-3 | | Hentges, S | L | Hentges, S | | Barria, J | R |
| 8/21/2021 | | | LAA | L | 4-5 | | McKenzie, T | R | McKenzie, T | | Detmers, R | L |
| 8/22/2021 | | | LAA | W | 5-4 | | Quantrill, C | R | Wittgren, N | | Suarez, J | L |
| 8/24/2021 | | | Tex | L | 2-3 | | Morgan, E | R | Karinchak, J | | Hearn, T | L |
| 8/25/2021 | | | Tex | W | 5-2 | | Plesac, Z | R | Plesac, Z | Clase, E | Latz, J | L |
| 8/26/2021 | | | Tex | W | 10-4 | | Hentges, S | L | Hentges, S | | Lyles, J | R |
| 8/27/2021 | | | Bos | L | 1-4 | | Allen, L | L | Wittgren, N | | Rodriguez, E | L |
| 8/28/2021 | | | Bos | W | 3-2 | 10 | Quantrill, C | R | Garza, J | | Eovaldi, N | R |
| 8/29/2021 | | | Bos | L | 3-10 | | Morgan, E | R | Morgan, E | | Houck, T | R |
| 8/31/2021 | | @ | KC | W | 9-8 | | Plesac, Z | R | Plesac, Z | Clase, E | Junis, J | R |
| 9/1/2021 | | @ | KC | W | 9-3 | | Allen, L | L | Allen, L | | Kowar, J | R |
| 9/2/2021 | | @ | KC | L | 2-3 | | McKenzie, T | R | Parker, B | | Minor, M | L |
| 9/3/2021 | | @ | Bos | W | 11-0 | | Quantrill, C | R | Quantrill, C | | Eovaldi, N | R |
| 9/4/2021 | | @ | Bos | L | 1-3 | | Morgan, E | R | Shaw, B | | Houck, T | R |
| 9/5/2021 | | @ | Bos | L | 4-7 | | Plesac, Z | R | Plesac, Z | | Crawford, K | R |
| 9/6/2021 | | | Min | L | 7-16 | | Allen, L | L | Allen, L | | Ober, B | R |
| 9/7/2021 | | | Min | L | 1-14 | | Civale, A | R | Civale, A | | Gant, J | R |
| 9/8/2021 | | | Min | L | 0-10 | | McKenzie, T | R | McKenzie, T | | Ryan, J | R |
| 9/9/2021 | | | Min | W | 12-0 | | Quantrill, C | R | Quantrill, C | | Albers, A | L |
| 9/10/2021 | | | Mil | L | 3-7 | | Morgan, E | R | Morgan, E | | Houser, A | R |
| 9/11/2021 | | | Mil | L | 2-12 | | Plesac, Z | R | Plesac, Z | | Burnes, C | R |
| 9/12/2021 | | | Mil | L | 0-6 | | Civale, A | R | Civale, A | | Lauer, E | L |
| 9/14/2021 | 1 | @ | Min | L | 1-2 | 7 | McKenzie, T | R | McKenzie, T | | Ryan, J | R |
| 9/14/2021 | 2 | @ | Min | L | 1-2 | 7 | Allen, L | L | Garza, J | | Barnes, C | L |
| 9/15/2021 | | @ | Min | L | 3-5 | | Quantrill, C | R | Quantrill, C | | Jax, G | R |
| 9/17/2021 | | @ | NYA | W | 2-1 | | Plesac, Z | R | Plesac, Z | Clase, E | Kluber, C | R |
| 9/18/2021 | | @ | NYA | W | 6-0 | | Civale, A | R | Civale, A | | Gil, L | R |
| 9/19/2021 | | @ | NYA | L | 2-7 | | Morgan, E | R | Morgan, E | | Cole, G | R |
| 9/20/2021 | 1 | | KC | W | 9-1 | 7 | McKenzie, T | R | Stephan, T | | Singer, B | R |
| 9/20/2021 | 2 | | KC | W | 1-0 | 7 | Wittgren, N | R | Clase, E | | Payamps, J | R |
| 9/21/2021 | | | KC | W | 10-1 | | Quantrill, C | R | Quantrill, C | | Lynch, D | L |
| 9/23/2021 | 1 | | ChA | L | 2-3 | 7 | Civale, A | R | Civale, A | | Lopez, R | R |
| 9/23/2021 | 2 | | ChA | W | 2-0 | 7 | Plesac, Z | R | Plesac, Z | Clase, E | Kopech, M | R |
| 9/24/2021 | | | ChA | L | 2-4 | | Bieber, S | R | Bieber, S | | Cease, D | R |
| 9/25/2021 | | | ChA | L | 1-5 | | Morgan, E | R | Morgan, E | | Lynn, L | R |
| 9/26/2021 | | | ChA | W | 3-2 | | McKenzie, T | R | Stephan, T | Clase, E | Giolito, L | R |
| 9/27/2021 | | | KC | W | 11-1 | | Quantrill, C | R | Quantrill, C | | Kowar, J | R |
| 9/28/2021 | | @ | KC | L | 3-4 | | Civale, A | R | Wittgren, N | | Singer, B | R |
| 9/29/2021 | | @ | KC | W | 4-1 | | Plesac, Z | R | Plesac, Z | Clase, E | Lynch, D | L |
| 9/30/2021 | | @ | KC | L | 3-5 | | Bieber, S | R | Bieber, S | | Zerpa, A | L |
| 10/1/2021 | | @ | Tex | L | 6-8 | | Morgan, E | R | Wittgren, N | | Howard, S | R |
| 10/2/2021 | | @ | Tex | L | 5-9 | | McKenzie, T | R | McKenzie, T | | Lyles, J | R |
| 10/3/2021 | | @ | Tex | W | 5-2 | | Civale, A | R | Civale, A | Clase, E | Dunning, D | R |
| Other |
| | | | | | | | | Cumulative |
| Date | # | | Opp | | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# |
| 9/29/2014 | | | Det | L | | 2 | 5 | 85 | 78 | .521 | 4-6 | L1 | 163 |
| 4/1/2021 | | @ | Det | W | Ramirez, J | 9 | 5 | 1 | 0 | 1.000 | 1-0 | W1 | 1 |
| 4/3/2021 | | @ | Det | L | | 5 | 6 | 1 | 1 | .500 | 1-1 | L1 | 2 |
| 4/4/2021 | | @ | Det | W | Rosario, E | 9 | 6 | 2 | 1 | .667 | 2-1 | W1 | 3 |
| 4/5/2021 | | | KC | L | | 1 | 2 | 2 | 2 | .500 | 2-2 | L1 | 4 |
| 4/7/2021 | | | KC | W | Bauers, J | 8 | 1 | 3 | 2 | .600 | 3-2 | W1 | 5 |
| 4/9/2021 | | | Det | W | Hernandez, C | 11 | 4 | 4 | 2 | .667 | 4-2 | W2 | 6 |
| 4/10/2021 | | | Det | W | Rosario, A | 5 | 2 | 5 | 2 | .714 | 5-2 | W3 | 7 |
| 4/11/2021 | | | Det | W | Ramirez, J | 9 | 7 | 6 | 2 | .750 | 6-2 | W4 | 8 |
| 4/12/2021 | | @ | ChA | L | | 5 | 12 | 6 | 3 | .667 | 6-3 | L1 | 9 |
| 4/13/2021 | | @ | ChA | W | Ramirez, J | 2 | 1 | 7 | 3 | .700 | 7-3 | W1 | 10 |
| 4/14/2021 | | @ | ChA | L | | 3 | 10 | 7 | 4 | .636 | 6-4 | L1 | 11 |
| 4/15/2021 | | @ | ChA | W | Bauers, J | 2 | 0 | 8 | 4 | .667 | 7-3 | W1 | 12 |
| 4/16/2021 | | @ | Cin | L | | 5 | 6 | 8 | 5 | .615 | 6-4 | L1 | 13 |
| 4/17/2021 | | @ | Cin | L | | 6 | 13 | 8 | 6 | .571 | 6-4 | L2 | 14 |
| 4/18/2021 | | @ | Cin | W | Chang, Y | 3 | 2 | 9 | 6 | .600 | 6-4 | W1 | 15 |
| 4/20/2021 | | | ChA | L | | 2 | 7 | 9 | 7 | .563 | 5-5 | L1 | 16 |
| 4/22/2021 | | | NYA | W | Naylor, J | 13 | 1 | 10 | 7 | .588 | 5-5 | W1 | 17 |
| 4/23/2021 | | | NYA | L | | 1 | 5 | 10 | 8 | .556 | 4-6 | L1 | 18 |
| 4/24/2021 | | | NYA | L | | 2 | 3 | 10 | 9 | .526 | 4-6 | L2 | 19 |
| 4/25/2021 | | | NYA | W | Rosario, E | 6 | 3 | 11 | 9 | .550 | 4-6 | W1 | 20 |
| 4/26/2021 | | | Min | W | Luplow, J | 6 | 3 | 12 | 9 | .571 | 5-5 | W2 | 21 |
| 4/27/2021 | | | Min | L | | 3 | 5 | 12 | 10 | .545 | 4-6 | L1 | 22 |
| 4/28/2021 | | | Min | W | Naylor, J | 11 | 8 | 13 | 10 | .565 | 5-5 | W1 | 23 |
| 4/30/2021 | | @ | ChA | W | Luplow, J | 9 | 3 | 14 | 10 | .583 | 6-4 | W2 | 24 |
| 5/1/2021 | | @ | ChA | L | | 2 | 7 | 14 | 11 | .560 | 5-5 | L1 | 25 |
| 5/2/2021 | | @ | ChA | W | Gimenez, A | 4 | 1 | 15 | 11 | .577 | 6-4 | W1 | 26 |
| 5/3/2021 | | @ | KC | W | Chang, Y | 6 | 5 | 16 | 11 | .593 | 6-4 | W2 | 27 |
| 5/4/2021 | | @ | KC | W | Rosario, A | 6 | 5 | 17 | 11 | .607 | 7-3 | W3 | 28 |
| 5/5/2021 | | @ | KC | L | | 3 | 9 | 17 | 12 | .586 | 7-3 | L1 | 29 |
| 5/6/2021 | | @ | KC | W | Reyes, F | 6 | 2 | 18 | 12 | .600 | 7-3 | W1 | 30 |
| 5/7/2021 | | | Cin | W | Rosario, A | 9 | 4 | 19 | 12 | .613 | 7-3 | W2 | 31 |
| 5/8/2021 | | | Cin | L | | 4 | 5 | 19 | 13 | .594 | 7-3 | L1 | 32 |
| 5/11/2021 | | | ChN | W | Rosario, E | 4 | 0 | 20 | 13 | .606 | 7-3 | W1 | 33 |
| 5/12/2021 | | | ChN | L | | 2 | 3 | 20 | 14 | .588 | 6-4 | L1 | 34 |
| 5/13/2021 | | @ | Sea | W | Rosario, E | 5 | 4 | 21 | 14 | .600 | 7-3 | W1 | 35 |
| 5/14/2021 | | @ | Sea | L | | 1 | 7 | 21 | 15 | .583 | 6-4 | L1 | 36 |
| 5/15/2021 | | @ | Sea | W | Ramirez, J | 3 | 2 | 22 | 15 | .595 | 6-4 | W1 | 37 |
| 5/16/2021 | | @ | Sea | L | | 3 | 4 | 22 | 16 | .579 | 5-5 | L1 | 38 |
| 5/17/2021 | | @ | LAA | L | | 0 | 5 | 22 | 17 | .564 | 5-5 | L2 | 39 |
| 5/18/2021 | | @ | LAA | W | Rosario, E | 3 | 0 | 23 | 17 | .575 | 5-5 | W1 | 40 |
| 5/19/2021 | | @ | LAA | L | | 0 | 3 | 23 | 18 | .561 | 4-6 | L1 | 41 |
| 5/21/2021 | | | Min | L | | 2 | 6 | 23 | 19 | .548 | 4-6 | L2 | 42 |
| 5/22/2021 | | | Min | W | Ramirez, J | 6 | 2 | 24 | 19 | .558 | 4-6 | W1 | 43 |
| 5/23/2021 | | | Min | W | | 3 | 2 | 25 | 19 | .568 | 5-5 | W2 | 44 |
| 5/24/2021 | | @ | Det | W | Naylor, J | 10 | 9 | 26 | 19 | .578 | 5-5 | W3 | 45 |
| 5/25/2021 | | @ | Det | W | Ramirez, J | 10 | 6 | 27 | 19 | .587 | 6-4 | W4 | 46 |
| 5/26/2021 | | @ | Det | L | | 3 | 14 | 27 | 20 | .574 | 5-5 | L1 | 47 |
| 5/27/2021 | | @ | Det | L | | 1 | 3 | 27 | 21 | .563 | 5-5 | L2 | 48 |
| 5/28/2021 | | | Tor | W | Rosario, A | 6 | 3 | 28 | 21 | .571 | 6-4 | W1 | 49 |
| 5/30/2021 | 1 | | Tor | L | | 5 | 7 | 28 | 22 | .560 | 5-5 | L1 | 50 |
| 5/30/2021 | 2 | | Tor | L | | 1 | 2 | 28 | 23 | .549 | 5-5 | L2 | 51 |
| 5/31/2021 | 1 | | ChA | L | | 0 | 5 | 28 | 24 | .538 | 5-5 | L3 | 52 |
| 5/31/2021 | 2 | | ChA | W | Zimmer, B | 1 | 0 | 29 | 24 | .547 | 5-5 | W1 | 53 |
| 6/1/2021 | | | ChA | W | Zimmer, B | 10 | 5 | 30 | 24 | .556 | 5-5 | W2 | 54 |
| 6/4/2021 | | @ | Bal | L | | 5 | 8 | 30 | 25 | .545 | 4-6 | L1 | 55 |
| 6/5/2021 | | @ | Bal | L | | 4 | 6 | 30 | 26 | .536 | 3-7 | L2 | 56 |
| 6/6/2021 | | @ | Bal | L | | 3 | 8 | 30 | 27 | .526 | 3-7 | L3 | 57 |
| 6/8/2021 | | @ | StL | L | | 0 | 3 | 30 | 28 | .517 | 3-7 | L4 | 58 |
| 6/9/2021 | | @ | StL | L | | 3 | 6 | 30 | 29 | .508 | 2-8 | L5 | 59 |
| 6/11/2021 | | | Sea | W | Bradley, B | 9 | 6 | 31 | 29 | .517 | 3-7 | W1 | 60 |
| 6/12/2021 | | | Sea | W | Rosario, A | 3 | 2 | 32 | 29 | .525 | 4-6 | W2 | 61 |
| 6/13/2021 | | | Sea | W | Rosario, A | 6 | 2 | 33 | 29 | .532 | 5-5 | W3 | 62 |
| 6/14/2021 | | | Bal | L | | 3 | 10 | 33 | 30 | .524 | 4-6 | L1 | 63 |
| 6/15/2021 | | | Bal | W | Zimmer, B | 4 | 3 | 34 | 30 | .531 | 4-6 | W1 | 64 |
| 6/16/2021 | | | Bal | L | | 1 | 4 | 34 | 31 | .523 | 4-6 | L1 | 65 |
| 6/17/2021 | | | Bal | W | Zimmer, B | 8 | 3 | 35 | 31 | .530 | 5-5 | W1 | 66 |
| 6/18/2021 | | @ | Pit | L | | 6 | 8 | 35 | 32 | .522 | 5-5 | L1 | 67 |
| 6/19/2021 | | @ | Pit | W | Hernandez, C | 7 | 2 | 36 | 32 | .529 | 6-4 | W1 | 68 |
| 6/20/2021 | | @ | Pit | W | Rosario, A | 4 | 1 | 37 | 32 | .536 | 7-3 | W2 | 69 |
| 6/21/2021 | | @ | ChN | L | | 2 | 5 | 37 | 33 | .529 | 6-4 | L1 | 70 |
| 6/22/2021 | | @ | ChN | W | Lavarnway, R | 6 | 5 | 38 | 33 | .535 | 6-4 | W1 | 71 |
| 6/24/2021 | | @ | Min | L | | 1 | 5 | 38 | 34 | .528 | 5-5 | L1 | 72 |
| 6/25/2021 | | @ | Min | W | Rosario, E | 3 | 0 | 39 | 34 | .534 | 6-4 | W1 | 73 |
| 6/27/2021 | | @ | Min | L | | 1 | 3 | 39 | 35 | .527 | 5-5 | L1 | 74 |
| 6/28/2021 | | | Det | W | Rosario, E | 7 | 1 | 40 | 35 | .533 | 6-4 | W1 | 75 |
| 6/30/2021 | 1 | | Det | W | Chang, Y | 3 | 2 | 41 | 35 | .539 | 6-4 | W2 | 76 |
| 6/30/2021 | 2 | | Det | L | | 3 | 7 | 41 | 36 | .532 | 6-4 | L1 | 77 |
| 7/1/2021 | | | Hou | L | | 2 | 3 | 41 | 37 | .526 | 5-5 | L2 | 78 |
| 7/2/2021 | | | Hou | L | | 3 | 9 | 41 | 38 | .519 | 4-6 | L3 | 79 |
| 7/3/2021 | | | Hou | W | Clement, E | 6 | 1 | 42 | 38 | .525 | 5-5 | W1 | 80 |
| 7/4/2021 | | | Hou | W | Clement, E | 3 | 1 | 43 | 38 | .531 | 5-5 | W2 | 81 |
| 7/5/2021 | | @ | Tam | L | | 4 | 7 | 43 | 39 | .524 | 5-5 | L1 | 82 |
| 7/7/2021 | 1 | @ | Tam | L | | 3 | 4 | 43 | 40 | .518 | 4-6 | L2 | 83 |
| 7/7/2021 | 2 | @ | Tam | L | | 1 | 3 | 43 | 41 | .512 | 4-6 | L3 | 84 |
| 7/8/2021 | | | KC | W | Zimmer, B | 4 | 1 | 44 | 41 | .518 | 4-6 | W1 | 85 |
| 7/9/2021 | | | KC | W | Rosario, A | 8 | 3 | 45 | 41 | .523 | 4-6 | W2 | 86 |
| 7/10/2021 | | | KC | W | Bradley, B | 4 | 0 | 46 | 41 | .529 | 5-5 | W3 | 87 |
| 7/16/2021 | | @ | Oak | L | | 2 | 9 | 46 | 42 | .523 | 5-5 | L1 | 88 |
| 7/17/2021 | | @ | Oak | W | Bradley, B | 3 | 2 | 47 | 42 | .528 | 6-4 | W1 | 89 |
| 7/18/2021 | | @ | Oak | L | | 4 | 7 | 47 | 43 | .522 | 5-5 | L1 | 90 |
| 7/19/2021 | | @ | Hou | W | Hernandez, C | 3 | 2 | 48 | 43 | .527 | 5-5 | W1 | 91 |
| 7/20/2021 | | @ | Hou | L | | 2 | 3 | 48 | 44 | .522 | 5-5 | L1 | 92 |
| 7/21/2021 | | @ | Hou | W | Reyes, F | 3 | 0 | 49 | 44 | .527 | 6-4 | W1 | 93 |
| 7/22/2021 | | | Tam | L | | 6 | 9 | 49 | 45 | .521 | 6-4 | L1 | 94 |
| 7/23/2021 | | | Tam | L | | 1 | 16 | 49 | 46 | .516 | 5-5 | L2 | 95 |
| 7/24/2021 | | | Tam | L | | 2 | 3 | 49 | 47 | .510 | 4-6 | L3 | 96 |
| 7/25/2021 | | | Tam | W | Rosario, A | 12 | 10 | 50 | 47 | .515 | 4-6 | W1 | 97 |
| 7/27/2021 | | | StL | W | Bradley, B | 4 | 3 | 51 | 47 | .520 | 5-5 | W2 | 98 |
| 7/28/2021 | | | StL | W | Mercado, O | 4 | 2 | 52 | 47 | .525 | 5-5 | W3 | 99 |
| 7/30/2021 | | @ | ChA | W | Ramirez, J | 3 | 0 | 53 | 47 | .530 | 6-4 | W4 | 100 |
| 7/31/2021 | | @ | ChA | W | Miller, O | 3 | 0 | 54 | 47 | .535 | 6-4 | W5 | 101 |
| 8/1/2021 | | @ | ChA | W | Ramirez, J | 12 | 8 | 55 | 47 | .539 | 7-3 | W6 | 102 |
| 8/2/2021 | | @ | Tor | L | | 2 | 4 | 55 | 48 | .534 | 6-4 | L1 | 103 |
| 8/3/2021 | | @ | Tor | W | Bradley, B | 10 | 3 | 56 | 48 | .538 | 7-3 | W1 | 104 |
| 8/4/2021 | | @ | Tor | L | | 2 | 4 | 56 | 49 | .533 | 7-3 | L1 | 105 |
| 8/5/2021 | | @ | Tor | W | Hedges, A | 3 | 0 | 57 | 49 | .538 | 8-2 | W1 | 106 |
| 8/6/2021 | | | Det | L | | 3 | 7 | 57 | 50 | .533 | 7-3 | L1 | 107 |
| 8/7/2021 | | | Det | W | Straw, M | 2 | 1 | 58 | 50 | .537 | 7-3 | W1 | 108 |
| 8/8/2021 | | | Det | W | Zimmer, B | 11 | 2 | 59 | 50 | .541 | 7-3 | W2 | 109 |
| 8/9/2021 | | | Cin | L | | 3 | 4 | 59 | 51 | .536 | 6-4 | L1 | 110 |
| 8/10/2021 | | | Oak | W | Reyes, F | 4 | 2 | 60 | 51 | .541 | 6-4 | W1 | 111 |
| 8/11/2021 | | | Oak | W | Ramirez, J | 4 | 0 | 61 | 51 | .545 | 6-4 | W2 | 112 |
| 8/12/2021 | | | Oak | W | | 4 | 3 | 62 | 51 | .549 | 7-3 | W3 | 113 |
| 8/13/2021 | | @ | Det | L | | 1 | 6 | 62 | 52 | .544 | 6-4 | L1 | 114 |
| 8/14/2021 | | @ | Det | W | Mercado, O | 10 | 7 | 63 | 52 | .548 | 7-3 | W1 | 115 |
| 8/15/2021 | | @ | Det | W | Reyes, F | 9 | 4 | 64 | 52 | .552 | 7-3 | W2 | 116 |
| 8/16/2021 | | @ | Min | L | | 8 | 12 | 64 | 53 | .547 | 7-3 | L1 | 117 |
| 8/17/2021 | | @ | Min | W | Rosario, A | 5 | 2 | 65 | 53 | .551 | 7-3 | W1 | 118 |
| 8/18/2021 | | @ | Min | W | Ramirez, J | 4 | 0 | 66 | 53 | .555 | 7-3 | W2 | 119 |
| 8/20/2021 | | | LAA | W | Chang, Y | 6 | 3 | 67 | 53 | .558 | 8-2 | W3 | 120 |
| 8/21/2021 | | | LAA | L | | 4 | 5 | 67 | 54 | .554 | 7-3 | L1 | 121 |
| 8/22/2021 | | | LAA | W | Rosario, A | 5 | 4 | 68 | 54 | .557 | 7-3 | W1 | 122 |
| 8/24/2021 | | | Tex | L | | 2 | 3 | 68 | 55 | .553 | 6-4 | L1 | 123 |
| 8/25/2021 | | | Tex | W | Mercado, O | 5 | 2 | 69 | 55 | .556 | 7-3 | W1 | 124 |
| 8/26/2021 | | | Tex | W | Rosario, A | 10 | 4 | 70 | 55 | .560 | 7-3 | W2 | 125 |
| 8/27/2021 | | | Bos | L | | 1 | 4 | 70 | 56 | .556 | 6-4 | L1 | 126 |
| 8/28/2021 | | | Bos | W | Rosario, A | 3 | 2 | 71 | 56 | .559 | 7-3 | W1 | 127 |
| 8/29/2021 | | | Bos | L | | 3 | 10 | 71 | 57 | .555 | 6-4 | L1 | 128 |
| 8/31/2021 | | @ | KC | W | Reyes, F | 9 | 8 | 72 | 57 | .558 | 6-4 | W1 | 129 |
| 9/1/2021 | | @ | KC | W | Zimmer, B | 9 | 3 | 73 | 57 | .562 | 6-4 | W2 | 130 |
| 9/2/2021 | | @ | KC | L | | 2 | 3 | 73 | 58 | .557 | 6-4 | L1 | 131 |
| 9/3/2021 | | @ | Bos | W | Hedges, A | 11 | 0 | 74 | 58 | .561 | 6-4 | W1 | 132 |
| 9/4/2021 | | @ | Bos | L | | 1 | 3 | 74 | 59 | .556 | 6-4 | L1 | 133 |
| 9/5/2021 | | @ | Bos | L | | 4 | 7 | 74 | 60 | .552 | 5-5 | L2 | 134 |
| 9/6/2021 | | | Min | L | | 7 | 16 | 74 | 61 | .548 | 4-6 | L3 | 135 |
| 9/7/2021 | | | Min | L | | 1 | 14 | 74 | 62 | .544 | 4-6 | L4 | 136 |
| 9/8/2021 | | | Min | L | | 0 | 10 | 74 | 63 | .540 | 3-7 | L5 | 137 |
| 9/9/2021 | | | Min | W | Ramirez, H | 12 | 0 | 75 | 63 | .543 | 4-6 | W1 | 138 |
| 9/10/2021 | | | Mil | L | | 3 | 7 | 75 | 64 | .540 | 3-7 | L1 | 139 |
| 9/11/2021 | | | Mil | L | | 2 | 12 | 75 | 65 | .536 | 2-8 | L2 | 140 |
| 9/12/2021 | | | Mil | L | | 0 | 6 | 75 | 66 | .532 | 2-8 | L3 | 141 |
| 9/14/2021 | 1 | @ | Min | L | | 1 | 2 | 75 | 67 | .528 | 1-9 | L4 | 142 |
| 9/14/2021 | 2 | @ | Min | L | | 1 | 2 | 75 | 68 | .524 | 1-9 | L5 | 143 |
| 9/15/2021 | | @ | Min | L | | 3 | 5 | 75 | 69 | .521 | 1-9 | L6 | 144 |
| 9/17/2021 | | @ | NYA | W | Zimmer, B | 2 | 1 | 76 | 69 | .524 | 2-8 | W1 | 145 |
| 9/18/2021 | | @ | NYA | W | Ramirez, J | 6 | 0 | 77 | 69 | .527 | 3-7 | W2 | 146 |
| 9/19/2021 | | @ | NYA | L | | 2 | 7 | 77 | 70 | .524 | 3-7 | L1 | 147 |
| 9/20/2021 | 1 | | KC | W | Zimmer, B | 9 | 1 | 78 | 70 | .527 | 3-7 | W1 | 148 |
| 9/20/2021 | 2 | | KC | W | Perez, R | 1 | 0 | 79 | 70 | .530 | 4-6 | W2 | 149 |
| 9/21/2021 | | | KC | W | Ramirez, J | 10 | 1 | 80 | 70 | .533 | 5-5 | W3 | 150 |
| 9/23/2021 | 1 | | ChA | L | | 2 | 3 | 80 | 71 | .530 | 5-5 | L1 | 151 |
| 9/23/2021 | 2 | | ChA | W | Reyes, F | 2 | 0 | 81 | 71 | .533 | 6-4 | W1 | 152 |
| 9/24/2021 | | | ChA | L | | 2 | 4 | 81 | 72 | .529 | 6-4 | L1 | 153 |
| 9/25/2021 | | | ChA | L | | 1 | 5 | 81 | 73 | .526 | 6-4 | L2 | 154 |
| 9/26/2021 | | | ChA | W | Straw, M | 3 | 2 | 82 | 73 | .529 | 6-4 | W1 | 155 |
| 9/27/2021 | | | KC | W | Reyes, F | 11 | 1 | 83 | 73 | .532 | 6-4 | W2 | 156 |
| 9/28/2021 | | @ | KC | L | | 3 | 4 | 83 | 74 | .529 | 6-4 | L1 | 157 |
| 9/29/2021 | | @ | KC | W | Ramirez, H | 4 | 1 | 84 | 74 | .532 | 6-4 | W1 | 158 |
| 9/30/2021 | | @ | KC | L | | 3 | 5 | 84 | 75 | .528 | 5-5 | L1 | 159 |
| 10/1/2021 | | @ | Tex | L | | 6 | 8 | 84 | 76 | .525 | 4-6 | L2 | 160 |
| 10/2/2021 | | @ | Tex | L | | 5 | 9 | 84 | 77 | .522 | 4-6 | L3 | 161 |
| 10/3/2021 | | @ | Tex | W | Straw, M | 5 | 2 | 85 | 77 | .525 | 4-6 | W1 | 162 |