| Transactions | |||||||
| Date | Team | Player | Type | OthTm | EffDate | When | Appl |
| 4/10/1961 | Cle | Stigman | Placed on disabled list | Before | Yes | ||
| 5/3/1961 | Cle | Essegian,C | Acquired via trade | KC | Before | Yes | |
| 5/4/1961 | Cle | Hamilton | Demoted to reserve roster | Before | Yes | ||
| 5/4/1961 | Cle | Jones,H | Demoted to reserve roster | Before | Yes | ||
| 5/7/1961 | Cle | Bond | Demoted to reserve roster | After | Yes | ||
| 5/10/1961 | Cle | Morgan,J | Traded away | StL | Before | Yes | |
| 5/10/1961 | Cle | Nieman,B | Acquired via trade | StL | Before | Yes | |
| 5/15/1961 | Cle | Nieman,B | Day-to-day | Before | Yes | ||
| 5/29/1961 | Cle | Temple | Day-to-day | Before | Yes | ||
| 6/2/1961 | Cle | Temple | Healthy | Before | Yes | ||
| 6/5/1961 | Cle | Heman,R | Traded away | LAA | Before | Yes | |
| 6/5/1961 | Cle | Stigman | Activated from disabled list | Before | Yes | ||
| 6/11/1961 | Cle | Nieman,B | Healthy | Before | Yes | ||
| 6/12/1961 | Cle | Latman | Day-to-day | Before | Yes | ||
| 6/16/1961 | Cle | Latman | Healthy | Before | Yes | ||
| 6/17/1961 | Cle | Latman | Day-to-day | Before | Yes | ||
| 6/20/1961 | Cle | Latman | Healthy | Before | Yes | ||
| 6/25/1961 | Cle | Temple | In the doghouse | Before | Yes | ||
| 6/28/1961 | Cle | Piersall | Day-to-day | Between | Yes | ||
| 6/30/1961 | Cle | Piersall | Healthy | Before | Yes | ||
| 7/2/1961 | Cle | Piersall | Day-to-day | Before | Yes | ||
| 7/2/1961 | Cle | Temple | Out of doghouse | Before | Yes | ||
| 7/3/1961 | Cle | Aspromonte,K | Claimed on waivers | Before | Yes | ||
| 7/3/1961 | Cle | Kubiszyn | Demoted to reserve roster | Before | Yes | ||
| 7/4/1961 | Cle | Antonelli,J | Traded away | Mil | Before | Yes | |
| 7/5/1961 | Cle | Held | Day-to-day | Before | Yes | ||
| 7/7/1961 | Cle | Piersall | Healthy | Before | Yes | ||
| 7/7/1961 | Cle | Schaffernoth,J | Claimed on waivers | Before | Yes | ||
| 7/15/1961 | Cle | Power | Day-to-day | Before | Yes | ||
| 7/16/1961 | Cle | Held | Healthy | Before | Yes | ||
| 7/26/1961 | Cle | Power | Healthy | Before | Yes | ||
| 7/28/1961 | Cle | Bond | Promoted to active roster | Before | Yes | ||
| 7/28/1961 | Cle | Hale,B | Waived | Before | Yes | ||
| 8/13/1961 | Cle | Dailey | Promoted to active roster | Before | Yes | ||
| 8/13/1961 | Cle | Schaffernoth,J | Demoted to reserve roster | Before | Yes | ||
| 9/5/1961 | Cle | Piersall | Bereavement | Before | Yes | ||
| 9/9/1961 | Cle | Piersall | Return from bereavement | Before | Yes | ||
| 9/11/1961 | Cle | Cline | Promoted to active roster | Before | Yes | ||
| 9/11/1961 | Cle | Hamilton | Promoted to active roster | Before | Yes | ||
| 9/11/1961 | Cle | Jones,H | Promoted to active roster | Before | Yes | ||
| 9/11/1961 | Cle | Kubiszyn | Promoted to active roster | Before | Yes | ||
| 9/11/1961 | Cle | Luplow | Promoted to active roster | Before | Yes | ||
| 9/11/1961 | Cle | McDowell | Promoted to active roster | Before | Yes | ||
| 9/11/1961 | Cle | Schaffernoth,J | Promoted to active roster | Before | Yes | ||
| 9/16/1961 | Cle | McDowell | Day-to-day | Before | Yes | ||
| 10/3/1961 | Cle | McDowell | Healthy | Before | No | ||