| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When | Appl |
| 4/10/1961 | StL | Jackson,L | Day-to-day | | | Before | Yes |
| 4/21/1961 | StL | Jackson,L | Healthy | | | Before | Yes |
| 4/23/1961 | StL | Javier | Day-to-day | | | Between | Yes |
| 4/26/1961 | StL | Javier | Healthy | | | Before | Yes |
| 5/3/1961 | StL | Nieman,B | Day-to-day | | | Before | Yes |
| 5/3/1961 | StL | Tiefenauer | Demoted to reserve roster | | | Before | Yes |
| 5/9/1961 | StL | Nieman,B | Healthy | | | After | Yes |
| 5/10/1961 | StL | Crowe | Demoted to reserve roster | | | Before | Yes |
| 5/10/1961 | StL | Nieman,B | Traded away | Cle | | Before | Yes |
| 5/13/1961 | StL | McDermott,M | Personal leave | | | Before | Yes |
| 5/17/1961 | StL | McDermott,M | Return from personal leave | | | Before | Yes |
| 5/17/1961 | StL | Oliver | Demoted to reserve roster | | | Before | Yes |
| 5/17/1961 | StL | Schaffer | Promoted to active roster | | | Before | Yes |
| 5/29/1961 | StL | Cunningham | Day-to-day | | | Before | Yes |
| 5/30/1961 | StL | Cunningham | Healthy | | | Before | Yes |
| 5/30/1961 | StL | Landrum | Demoted to reserve roster | | | Before | Yes |
| 5/30/1961 | StL | Lillis,B | Acquired via trade | LAN | | Before | Yes |
| 5/30/1961 | StL | Spencer,D | Traded away | LAN | | Before | Yes |
| 5/30/1961 | StL | Warwick,C | Acquired via trade | LAN | | Before | Yes |
| 6/8/1961 | StL | Smith,HR | Day-to-day | | | Before | Yes |
| 6/11/1961 | StL | McCarver | Promoted to active roster | | | Before | Yes |
| 6/12/1961 | StL | Moryn,W | Waived | | | Before | Yes |
| 6/16/1961 | StL | Javier | Placed on disabled list | | | Before | Yes |
| 6/17/1961 | StL | Gotay | Promoted to active roster | | | Before | Yes |
| 6/19/1961 | StL | Smith,HR | Healthy | | | After | Yes |
| 6/20/1961 | StL | Smith,HR | Placed on disabled list | | | Before | Yes |
| 6/22/1961 | StL | Anderson,C | Promoted to active roster | | | Before | Yes |
| 6/30/1961 | StL | Buchek | Promoted to active roster | | | Before | Yes |
| 6/30/1961 | StL | Gotay | Demoted to reserve roster | | | Before | Yes |
| 7/9/1961 | StL | McDermott,M | Suspended | | | Before | Yes |
| 7/14/1961 | StL | McDermott,M | Reinstated | | | After | Yes |
| 7/15/1961 | StL | McDermott,M | Waived | | | Before | Yes |
| 7/16/1961 | StL | Javier | Activated from disabled list | | | Before | Yes |
| 7/20/1961 | StL | Bauta | Promoted to active roster | | | Before | Yes |
| 7/20/1961 | StL | Buchek | Demoted to reserve roster | | | Before | Yes |
| 7/28/1961 | StL | Olivares | Promoted to active roster | | | Before | Yes |
| 7/28/1961 | StL | Warwick,C | Demoted to reserve roster | | | Before | Yes |
| 7/31/1961 | StL | Cannizzaro | Promoted to active roster | | | Before | Yes |
| 7/31/1961 | StL | McCarver | Demoted to reserve roster | | | Before | Yes |
| 8/8/1961 | StL | Cunningham | Day-to-day | | | Before | Yes |
| 8/13/1961 | StL | Cunningham | Healthy | | | Before | Yes |
| 8/19/1961 | StL | Broglio | Day-to-day | | | Before | Yes |
| 8/24/1961 | StL | Broglio | Healthy | | | Before | Yes |
| 9/8/1961 | StL | Gotay | Promoted to active roster | | | Before | Yes |
| 9/11/1961 | StL | Buchek | Promoted to active roster | | | Before | Yes |
| 9/11/1961 | StL | Landrum | Promoted to active roster | | | Before | Yes |
| 9/11/1961 | StL | Oliver | Promoted to active roster | | | Before | Yes |
| 9/17/1961 | StL | Clemens | Promoted to active roster | | | Before | Yes |
| 9/17/1961 | StL | McCarver | Promoted to active roster | | | Before | Yes |
| 9/17/1961 | StL | Warwick,C | Promoted to active roster | | | Before | Yes |
| 9/17/1961 | StL | Washburn | Promoted to active roster | | | Before | Yes |